Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

57142

Name

RTN4

Synonymous

ASY|NI220/250|NOGO|NOGO-A|NOGOC|NSP|NSP-CL|Nbla00271|Nbla10545|Nogo-B|Nogo-C|RTN-X|RTN4-A|RTN4-B1|RTN4-B2|RTN4-C;reticulon 4;RTN4;reticulon 4

Definition

Human NogoA|My043 protein|foocen|neurite growth inhibitor 220|neurite outgrowth inhibitor|neuroendocrine-specific protein C homolog|reticulon 5|reticulon-4

Position

2p16.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

Nogo-isoform1(h) + Caspr(r) <==> Nogo-isoform1(h):Caspr(r) (binding)
Caspr(m) + Nogo-isoform1(h) + Kv1.1(m) <==> Caspr(m):Nogo-isoform1(h):Kv1.1(m) (binding)
Caspr(r) + Nogo-isoform1(h) + Kv1.1(r) <==> Caspr(r):Nogo-isoform1(h):Kv1.1(r) (binding)
RTN4(h) --> Nogo-isoform1(h) (expression).
SIRT2(h) + Nogo(h) <==> SIRT2(h):Nogo(h) (binding)
lrch4(h) + Nogo(h) <==> lrch4(h):Nogo(h) (binding)
SNAP-alpha(h) + Nogo(h) <==> SNAP-alpha(h):Nogo(h) (binding)
RabS10(h) + Nogo(h) <==> RabS10(h):Nogo(h) (binding)
FXR2(h) + Nogo(h) <==> FXR2(h):Nogo(h) (binding)
GPBP(h) + Nogo(h) <==> GPBP(h):Nogo(h) (binding)
NSPL2(h) + Nogo(h) <==> NSPL2(h):Nogo(h) (binding)
Maspardin(h) + Nogo(h) <==> Maspardin(h):Nogo(h) (binding)
Nogo(h) + plekhf2(h) <==> Nogo(h):plekhf2(h) (binding)
RTN4(h) --> Nogo(h) (expression).
RTN4(h) --> Nogo-isoform2(h) (expression).
RTN4(h) --> Nogo-isoform3(h) (expression).
RTN4(h) --> Nogo-isoform4(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

7Phosphoserine.Swiss-Prot 53.0
15Phosphoserine.Swiss-Prot 53.0
107Phosphoserine.Swiss-Prot 53.0
152Phosphoserine (By similarity).Swiss-Prot 53.0
182Phosphoserine (By similarity).Swiss-Prot 53.0
184Phosphoserine.Swiss-Prot 53.0
188Phosphothreonine.Swiss-Prot 53.0
446Phosphoserine (By similarity).Swiss-Prot 53.0
860Phosphoserine (By similarity).Swiss-Prot 53.0
863Phosphoserine (By similarity).Swiss-Prot 53.0
881Phosphoserine (By similarity).Swiss-Prot 53.0
889Phosphotyrosine (By similarity).Swiss-Prot 53.0
7Phosphoserine17081983Phospho.ELM 6.0
15Phosphoserine17081983Phospho.ELM 6.0
107Phosphoserine17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr2

Promoter: 55130738 - 55132738Agilent_014791

chr2

Promoter: 55129330 - 55131330Agilent_014791

chr2

Promoter: 55130738 - 55132738GSE27584

chr2

Promoter: 55129330 - 55131330GSE27584

chr2

Promoter: 55130738 - 55132738GSE27584

chr2

Promoter: 55130738 - 55132738GSE27584

chr2

Promoter: 55129330 - 55131330Agilent_014791_44K


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