| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 613 |
Name | BCR |
Synonymous | ALL|BCR1|CML|D22S11|D22S662|PHL;breakpoint cluster region;BCR;breakpoint cluster region |
Definition | BCR/FGFR1 chimera protein|FGFR1/BCR chimera protein|breakpoint cluster region protein|renal carcinoma antigen NY-REN-26 |
Position | 22q11.23 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
 |
Transcription Factors [Top] |
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Regulation From TransFac database |
bcr(h) + ABL-1b(h) <==> bcr(h):ABL-1b(h) (binding) | PLCgamma1(b) + bcr(h) <==> PLCgamma1(b):bcr(h) (binding) | RasGAP(h) + bcr(h) <==> RasGAP(h):bcr(h) (binding) | ARG(h) + bcr(h) <==> ARG(h):bcr(h) (binding) | p85alpha(b) + bcr(h) <==> p85alpha(b):bcr(h) (binding) | Lck(h) + bcr(h) <==> Lck(h):bcr(h) (binding) | bcr(h) + RhoGDI-1(h) <==> bcr(h):RhoGDI-1(h) (binding) | bcr(h) + IL-5Rbeta(h){pY} <==> bcr(h):IL-5Rbeta(h){pY} (binding) | bcr(h) + p53(h) <==> bcr(h):p53(h) (binding) | bcr(h) + RG4(h) <==> bcr(h):RG4(h) (binding) | BCR(h) --> bcr(h) (expression). | BCR(h) --> bcr-isoform1(h) (expression). | BCR(h) --> bcr-isoform2(h) (expression). |
|---|
Post Transcriptional Modification [Top] | |||
|
Location (AA) |
PTM type |
Literature |
Database |
177 | Phosphotyrosine. | Swiss-Prot 53.0 | 310 | Phosphothreonine. | Swiss-Prot 53.0 | 459 | Phosphoserine. | Swiss-Prot 53.0 | 463 | Phosphoserine. | Swiss-Prot 53.0 | 591 | Phosphotyrosine. | Swiss-Prot 53.0 | 644 | Phosphotyrosine. | Swiss-Prot 53.0 | 1264 | Phosphoserine. | Swiss-Prot 53.0 | 276 | Phosphotyrosine (Fes) | 8955135 | Phospho.ELM 6.0 | 246 | Phosphotyrosine (Fes) | 8955135 | Phospho.ELM 6.0 | 279 | Phosphotyrosine (Fes) | 8955135 | Phospho.ELM 6.0 | 283 | Phosphotyrosine (Fes) | 8955135 | Phospho.ELM 6.0 | 328 | Phosphotyrosine | 9467953 | Phospho.ELM 6.0 | 360 | Phosphotyrosine (Abl) | 9467953 | Phospho.ELM 6.0 | 177 | Phosphotyrosine (Fes;Abl;HCK) | 8955135;10405761;12522270;9178913;12124177;9407116 | Phospho.ELM 6.0 | 231 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 436 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 598 | Phosphotyrosine | 16497976 | Phospho.ELM 6.0 | 1264 | Phosphoserine (CK2 alpha) | 15144186;11084041 | Phospho.ELM 6.0 | 310 | Phosphothreonine | 12522270 | Phospho.ELM 6.0 | 459 | Phosphoserine | 12522270;17081983 | Phospho.ELM 6.0 | 463 | Phosphoserine | 12522270 | Phospho.ELM 6.0 | 591 | Phosphotyrosine | 12522270 | Phospho.ELM 6.0 | 644 | Phosphotyrosine | 12522270 | Phospho.ELM 6.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
|
Chromosome |
Location |
Source |
|---|---|---|
chr22 |
Promoter: 21851052 - 21853052 | Agilent_014791 |
chr22 |
Promoter: 21851052 - 21853052 | GoldenGate_Methylation_Cancer_Panel_I |
chr22 |
Promoter: 21851052 - 21853052 | GoldenGate_Methylation_Cancer_Panel_I |
chr22 |
Promoter: 21851052 - 21853052 | GSE27584 |
chr22 |
Promoter: 21851052 - 21853052 | GSE27584 |
chr22 |
Promoter: 21851052 - 21853052 | Agilent_014791_44K |
chr22 |
Promoter: 21851052 - 21853052 | Agilent_014791_44K |