Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6294

Name

SAFB

Synonymous

HAP|HET|SAF-B1|SAFB1;scaffold attachment factor B;SAFB;scaffold attachment factor B

Definition

HSP27 ERE-TATA-binding protein|HSP27 estrogen response element-TATA box-binding protein|Hsp27 ERE-TATA binding protein|SAB-B1|SAF-B|glutathione S-transferase fusion protein|heat-shock protein (HSP27) estrogen response element and TATA box-binding protein|

Position

19p13.3-p13.2

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

Ku70(h) + Ccte(h) + Pds5A(h) + PPIL1(h) + eIF-3gamma(h) + SAFB1(h) + Wapl(h) + Rad21(h) + SMC-3(h) + SMC1(h) + CAPER-alpha(h) + CNOT3(h) + NCoA-5(h) + SIAHBP1(h) + FBP(h) + HYPA(h) + SKIP(h) + SRm300(h) + SRm160(h) + p54nrb/NonO(h) + rbm25(h) + rbm8A(h) + Pinin(h) + Prp19(h) + cdc5L(h) + Snrp116(h) + Prpf8(h) + Sf3b-4(h) + Sf3b-2(h) + hnRNPM(h) + hnRNP-G(h) <==> Ku70(h):Ccte(h):Pds5A(h):PPIL1(h):eIF-3gamma(h):SAFB1(h):Wapl(h):Rad21(h):SMC-3(h):SMC1(h):CAPER-alpha(h):CNOT3(h):NCoA-5(h):SIAHBP1(h):FBP(h):HYPA(h):SKIP(h):SRm300(h):SRm160(h):p54nrb/NonO(h):rbm25(h):rbm8A(h):Pinin(h):Prp19(h):cdc5L(h):Snrp116(h):Prpf8(h):Sf3b-4(h):Sf3b-2(h):hnRNPM(h):hnRNP-G(h) (binding)
SAFB1(h) + Mi2-alpha(h) <==> SAFB1(h):Mi2-alpha(h) (binding)
SAFB(h) --> SAFB1(h) (expression).
SAFB(h) --> SAFB1(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

288Phosphoserine.Swiss-Prot 53.0
344Phosphoserine (By similarity).Swiss-Prot 53.0
384Phosphoserine.Swiss-Prot 53.0
589Phosphoserine.Swiss-Prot 53.0
601Phosphoserine.Swiss-Prot 53.0
604Phosphoserine.Swiss-Prot 53.0
808Phosphoserine.Swiss-Prot 53.0
604Phosphoserine15302935;17081983Phospho.ELM 6.0
288Phosphoserine15302935Phospho.ELM 6.0
601Phosphoserine15302935Phospho.ELM 6.0
416Phosphothreonine15302935Phospho.ELM 6.0
20Phosphoserine17081983Phospho.ELM 6.0
21Phosphoserine17081983Phospho.ELM 6.0
23Phosphoserine17081983Phospho.ELM 6.0
32Phosphoserine17081983Phospho.ELM 6.0
194Phosphothreonine17081983Phospho.ELM 6.0
234Phosphoserine17081983Phospho.ELM 6.0
344Phosphoserine17081983Phospho.ELM 6.0
384Phosphoserine17081983Phospho.ELM 6.0
555Phosphoserine17081983Phospho.ELM 6.0
589Phosphoserine17081983Phospho.ELM 6.0
621Phosphoserine17081983Phospho.ELM 6.0
808Phosphoserine17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr19

Promoter: 5572664 - 5574664GSE27584

chr19

Promoter: 5572664 - 5574664Agilent_014791_44K


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