Entrez Gene

Basic Information
Gene ID	6416
Name	MAP2K4
Synonymous	JNKK\|JNKK1\|MAPKK4\|MEK4\|MKK4\|PRKMK4\|SAPKK-1\|SAPKK1\|SEK1\|SERK1\|SKK1;mitogen-activated protein kinase kinase 4;MAP2K4;mitogen-activated protein kinase kinase 4
Definition	JNK-activated kinase 1\|JNK-activating kinase 1\|MAP kinase kinase 4\|MAPK/ERK kinase 4\|MAPKK 4\|MEK 4\|SAPK/ERK kinase 1\|c-Jun N-terminal kinase kinase 1\|dual specificity mitogen-activated protein kinase kinase 4\|stress-activated protein kinase kinase 1
Position	17p12
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
MKK4(h) --> Trx1(h){reC}2 (activation)
MKK4(h) + AKT(h){pT308}{pS473} <==> MKK4(h):AKT(h){pT308}{pS473} (binding)
MKK4(h) + 2 ATP --MEKK2(v.s.)--> MKK4(h){pS221}{pT225} + 2 ADP (phosphorylation)
MKK4(h) + 2 ATP --MEKK3(v.s.)--> MKK4(h){pS221}{pT225} + 2 ADP (phosphorylation)
MKK4(h) + POSH(m) <==> MKK4(h):POSH(m) (binding)
MKK4(h) --/ KLK3(h) (transrepression)
MKK4(h) --> Cyp24a1(r) (transactivation).
MKK4(h) + ATP --> MKK4(h){p} + ADP (phosphorylation)
AKT-1(h) + MKK4(h) <==> AKT-1(h):MKK4(h) (binding)
TRIB1(m.s.) + MKK4(h) <==> TRIB1(m.s.):MKK4(h) (binding)
MKK4(h) + ATP --> MKK4(h){pT261} + ADP (phosphorylation)
MAP2K4(h) --> MKK4(h) (expression).
MKK4(h){p} --PP2Calpha2(h)--> MKK4(h) + p (dephosphorylation)
JNK2(h) + ATP --MKK4(h)--> JNK2(h){p} + ADP (phosphorylation)
MKK4beta(h) + JNK2(h) <==> MKK4beta(h):JNK2(h) (binding)
MAP2K4(h) --> MKK4beta(h) (expression).
MAP2K4(h) --> MAP2K4(h) (expression).
hsa-miR-25 --/ MAP2K4(h) (predicted)
hsa-miR-92 --/ MAP2K4(h) (predicted)

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
261	Phosphothreonine (MAP2K4;MAP3K)	9162092;15911620;11053428;16000309	Phospho.ELM 6.0
257	Phosphoserine (MAP2K4)	9162092	Phospho.ELM 6.0