Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6416

Name

MAP2K4

Synonymous

JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1;mitogen-activated protein kinase kinase 4;MAP2K4;mitogen-activated protein kinase kinase 4

Definition

JNK-activated kinase 1|JNK-activating kinase 1|MAP kinase kinase 4|MAPK/ERK kinase 4|MAPKK 4|MEK 4|SAPK/ERK kinase 1|c-Jun N-terminal kinase kinase 1|dual specificity mitogen-activated protein kinase kinase 4|stress-activated protein kinase kinase 1

Position

17p12

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

MKK4(h) --> Trx1(h){reC}2 (activation)
MKK4(h) + AKT(h){pT308}{pS473} <==> MKK4(h):AKT(h){pT308}{pS473} (binding)
MKK4(h) + 2 ATP --MEKK2(v.s.)--> MKK4(h){pS221}{pT225} + 2 ADP (phosphorylation)
MKK4(h) + 2 ATP --MEKK3(v.s.)--> MKK4(h){pS221}{pT225} + 2 ADP (phosphorylation)
MKK4(h) + POSH(m) <==> MKK4(h):POSH(m) (binding)
MKK4(h) --/ KLK3(h) (transrepression)
MKK4(h) --> Cyp24a1(r) (transactivation).
MKK4(h) + ATP --> MKK4(h){p} + ADP (phosphorylation)
AKT-1(h) + MKK4(h) <==> AKT-1(h):MKK4(h) (binding)
TRIB1(m.s.) + MKK4(h) <==> TRIB1(m.s.):MKK4(h) (binding)
MKK4(h) + ATP --> MKK4(h){pT261} + ADP (phosphorylation)
MAP2K4(h) --> MKK4(h) (expression).
MKK4(h){p} --PP2Calpha2(h)--> MKK4(h) + p (dephosphorylation)
JNK2(h) + ATP --MKK4(h)--> JNK2(h){p} + ADP (phosphorylation)
MKK4beta(h) + JNK2(h) <==> MKK4beta(h):JNK2(h) (binding)
MAP2K4(h) --> MKK4beta(h) (expression).
MAP2K4(h) --> MAP2K4(h) (expression).
hsa-miR-25 --/ MAP2K4(h) (predicted)
hsa-miR-92 --/ MAP2K4(h) (predicted)

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

261Phosphothreonine (MAP2K4;MAP3K)9162092;15911620;11053428;16000309Phospho.ELM 6.0
257Phosphoserine (MAP2K4)9162092Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr17

Promoter: 11863360 - 11865360Agilent_014791

chr17

Promoter: 11863360 - 11865360GSE27584

chr17

Promoter: 11863360 - 11865360Agilent_014791_44K


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