Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

657

Name

BMPR1A

Synonymous

10q23del|ACVRLK3|ALK3|CD292|SKR5;bone morphogenetic protein receptor, type IA;BMPR1A;bone morphogenetic protein receptor, type IA

Definition

ALK-3|BMP type-1A receptor|BMPR-1A|activin A receptor, type II-like kinase 3|activin receptor-like kinase 3|bone morphogenetic protein receptor type-1A|serine/threonine-protein kinase receptor R5

Position

10q22.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

BMP2A(h) + BMPR-II(h) + BMPR-IA(h) <==> BMP2A(h):BMPR-IA(h):BMPR-II(h) (binding)
BMPR-IB(m) + BMPR-IA(h) <==> BMPR-IA(h):BMPR-IB(m) (binding)
BMPR-II(h) + BMPR-IA(h) <==> BMPR-IA(h):BMPR-II(h) (binding)
BMP2A(h) + BMPR-IB(m) + BMPR-IA(h) <==> BMP2A(h):BMPR-IA(h):BMPR-IB(m) (binding)
ActR-II(h) + BMPR-IA(h) + XIAP(h) <==> ActR-II(h):BMPR-IA(h):XIAP(h) (binding)
BMPR-IA(h) + TAB1(h) + XIAP(h) <==> BMPR-IA(h):XIAP(h):TAB1(h) (binding)
2 BMPR-IA(h) <==> BMPR-IA(h):BMPR-IA(h) (binding)
BMPR-IA(h) + XIAP(h) <==> BMPR-IA(h):XIAP(h) (binding)
BMP2A(h) + BMPR-IA(h) <==> BMP2A(h):BMPR-IA(h) (binding)
BMP7(h) + BMPR-IA(h) + BMPR-II(h) <==> BMP7(h):BMPR-IA(h):BMPR-II(h) (binding)
BMPR1A(h) --> BMPR-IA(h) (expression).
Smad1(h) + NTP --BMPR-IA(h)--> Smad1(h){p} + NDP (phosphorylation)
BMPR1A(h) --> BMPR-IA(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

73N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
215Phosphoserine.Swiss-Prot 53.0
216Phosphoserine.Swiss-Prot 53.0
218Phosphoserine.Swiss-Prot 53.0
220Phosphoserine.Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr10

Promoter: 88504876 - 88506876Agilent_014791

chr10

Promoter: 88504876 - 88506876GoldenGate_Methylation_Cancer_Panel_I

chr10

Promoter: 88504876 - 88506876GSE27584

chr10

Promoter: 88504876 - 88506876Agilent_014791_44K


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