Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

659

Name

BMPR2

Synonymous

BMPR-II|BMPR3|BMR2|BRK-3|POVD1|PPH1|T-ALK;bone morphogenetic protein receptor, type II (serine/threonine kinase);BMPR2;bone morphogenetic protein receptor, type II (serine/threonine kinase)

Definition

BMP type II receptor|BMP type-2 receptor|BMPR-2|bone morphogenetic protein receptor type II|bone morphogenetic protein receptor type-2|type II activin receptor-like kinase|type II receptor for bone morphogenetic protein-4

Position

2q33-q34

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

BMP2A(h) + BMPR-II(h) + BMPR-IA(h) <==> BMP2A(h):BMPR-IA(h):BMPR-II(h) (binding)
BMPR-II(h) + BMPR-IA(h) <==> BMPR-IA(h):BMPR-II(h) (binding)
BMPR-IB(m) + BMPR-II(h) <==> BMPR-IB(m):BMPR-II(h) (binding)
BMP2A(h) + BMPR-IB(m) + BMPR-II(h) <==> BMP2A(h):BMPR-IB(m):BMPR-II(h) (binding)
2 BMPR-II(h) <==> BMPR-II(h):BMPR-II(h) (binding)
BMP2A(h) + BMPR-II(h) <==> BMP2A(h):BMPR-II(h) (binding)
BMP6(h) + ALK-1(h) + BMPR-II(h) <==> BMP6(h):ALK-1(h):BMPR-II(h) (binding)
BMP6(h) + ActR-I(h) + BMPR-II(h) <==> BMP6(h):ActR-I(h):BMPR-II(h) (binding)
BMP6(h) + BMPR-IB(m) + BMPR-II(h) <==> BMP6(h):BMPR-IB(m):BMPR-II(h) (binding)
BMP7(h) + BMPR-II(h) + BMPR-IB(m) + Smad1(h) <==> BMP7(h):BMPR-II(h):BMPR-IB(m):Smad1(h) (binding)
BMP7(h) + BMPR-II(h) + BMPR-IB(m) + Smad5(m) <==> BMP7(h):BMPR-II(h):BMPR-IB(m):Smad5(m) (binding)
BMP7(h) + BMPR-II(h) + BMPR-IB(m) + Smad8(h) <==> BMP7(h):BMPR-II(h):BMPR-IB(m):Smad8(h) (binding)
BMP7(h) + BMPR-IA(h) + BMPR-II(h) <==> BMP7(h):BMPR-IA(h):BMPR-II(h) (binding)
BMP7(h) + BMPR-II(h) + BMPR-IB(h) <==> BMP7(h):BMPR-II(h):BMPR-IB(h) (binding)
BMPR2(h) --> BMPR-II(h) (expression).
BMPR2(h) --> BMPR-II(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

55N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
110N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
126N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
757Phosphoserine16155937Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr2

Promoter: 202948416 - 202950416Agilent_014791

chr2

Promoter: 202948416 - 202950416GoldenGate_Methylation_Cancer_Panel_I

chr2

Promoter: 202948416 - 202950416GSE27584

chr2

Promoter: 202948416 - 202950416Agilent_014791_44K


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