Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6595

Name

SMARCA2

Synonymous

BAF190|BRM|NCBRS|SNF2|SNF2L2|SNF2LA|SWI2|Sth1p|hBRM|hSNF2a;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2;SMARCA2;SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2

Definition

ATP-dependent helicase SMARCA2|BAF190B|BRG1-associated factor 190B|SNF2-alpha|SNF2/SWI2-like protein 2|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2|global transcription activator homologous sequence|probable global transcrip

Position

9p22.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

Brm(h) + HDAC1(h) + hdac2(h) + RbAp48(h) + BAF155(h) + BAF60A(h) + sin3a(h) <==> Brm(h):HDAC1(h):hdac2(h):RbAp48(h):BAF155(h):BAF60A(h):sin3a(h) (binding)
sin3a(h) + Brm(h) <==> sin3a(h):Brm(h) (binding)
Brm(h) + ER-alpha(h) <==> Brm(h):ER-alpha(h) (binding)
Brm(h) + ARID1B(h) <==> Brm(h):ARID1B(h) (binding)
Brm(h) + BAF250(h) <==> Brm(h):BAF250(h) (binding)
Brm(h) --> ABCB1(h) (DNA binding; transactivation).
BAF47(h) + BAF155(h) + BAF170(h) + Brm(h) + BRG1(h) + MCPH1(m.s.) <==> BAF47(h):BAF155(h):BAF170(h):Brm(h):BRG1(h):MCPH1(m.s.) (binding)
BRG1(h) + Brm(h) + MCT(h) <==> BRG1(h):Brm(h):MCT(h) (binding)
BAF155(h) + Brm(h) + MCPH1(m.s.) <==> BAF155(h):Brm(h):MCPH1(m.s.) (binding)
BAF47(h) + Brm(h) + BRG1(h) + BAF155(h) + BAF170(h) <==> BAF47(h):Brm(h):BRG1(h):BAF155(h):BAF170(h) (binding)
SMARCA2(h) --> Brm(h) (expression).
SMARCA2(h) --> Brm-L(h) (expression).
SMARCA2(h) --> Brm-S(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

325Phosphoserine.Swiss-Prot 53.0
587Phosphoserine.Swiss-Prot 53.0
952Phosphoserine.Swiss-Prot 53.0
1373Phosphoserine.Swiss-Prot 53.0
1414Phosphoserine.Swiss-Prot 53.0
1415Phosphoserine.Swiss-Prot 53.0
1547N6-acetyllysine.Swiss-Prot 53.0
1549N6-acetyllysine.Swiss-Prot 53.0
1551N6-acetyllysine.Swiss-Prot 53.0
1564Phosphoserine.Swiss-Prot 53.0
1568Phosphoserine.Swiss-Prot 53.0
587Phosphoserine15302935Phospho.ELM 6.0
1564Phosphoserine16097034;17081983Phospho.ELM 6.0
1568Phosphoserine16097034;17081983Phospho.ELM 6.0
322Phosphoserine17081983Phospho.ELM 6.0
325Phosphoserine17081983Phospho.ELM 6.0
611Phosphoserine17081983Phospho.ELM 6.0
1373Phosphoserine17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr9

Promoter: 2003842 - 2005842Agilent_014791

chr9

Promoter: 2003842 - 2005842GSE27584

chr9

Promoter: 2003842 - 2005842GSE27584

chr9

Promoter: 2003842 - 2005842Agilent_014791_44K

chr9

Promoter: 2003842 - 2005842Agilent_014791


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