Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

6711

Name

SPTBN1

Synonymous

ELF|HEL102|SPTB2|betaSpII;spectrin, beta, non-erythrocytic 1;SPTBN1;spectrin, beta, non-erythrocytic 1

Definition

beta-G spectrin|beta-II spectrin|beta-fodrin|beta-spectrin 2|beta-spectrin II|beta-spectrin non-erythrocytic 1|embryonic liver beta-fodrin|epididymis luminal protein 102|fodrin beta chain|spectrin beta chain, brain 1|spectrin beta chain, non-erythrocytic

Position

2p21

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

SPTBN1(h) --> beta2-spectrin-L(h) (expression).
beta2-spectrin(h) + sumo1(h) --> beta2-spectrin(h){sumo} (sumoylation)
beta2-spectrin(h) + lamin B(h) + actin(h) + vimentin(h) + plectin(h) <==> beta2-spectrin(h):lamin B(h):actin(h):vimentin(h):plectin(h) (binding)
plectin(h) + moesin(h) + beta2-spectrin(h) + actin(h) + vimentin(h) <==> plectin(h):moesin(h):beta2-spectrin(h):actin(h):vimentin(h) (binding)
vimentin(h) + actin(h) + beta2-spectrin(h) + plectin(h) <==> vimentin(h):actin(h):beta2-spectrin(h):plectin(h) (binding)
SPTBN1(h) --> beta2-spectrin(h) (expression).
SPTBN1(h) --> beta2-spectrin-S(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

999Phosphothreonine (By similarity).Swiss-Prot 53.0
1918Phosphoserine (By similarity).Swiss-Prot 53.0
2102Phosphoserine.Swiss-Prot 53.0
2115Phosphoserine (By similarity).Swiss-Prot 53.0
2128Phosphoserine.Swiss-Prot 53.0
2138Phosphoserine.Swiss-Prot 53.0
2165Phosphoserine.Swiss-Prot 53.0
2169Phosphoserine.Swiss-Prot 53.0
2195Phosphothreonine (By similarity).Swiss-Prot 53.0
2324O-linked (GlcNAc) (By similarity).Swiss-Prot 53.0
2138Phosphoserine15302935;17081983Phospho.ELM 6.0
2165Phosphoserine15302935;16083285;17081983Phospho.ELM 6.0
2102Phosphoserine16083285;17081983Phospho.ELM 6.0
2169Phosphoserine15302935Phospho.ELM 6.0
2128Phosphoserine15302935;17081983Phospho.ELM 6.0
2161Phosphoserine17081983Phospho.ELM 6.0
2164Phosphoserine17081983Phospho.ELM 6.0
2320Phosphothreonine17081983Phospho.ELM 6.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr2

Promoter: 54637535 - 54639535Agilent_014791

chr2

Promoter: 54637535 - 54639535GSE27584

chr2

Promoter: 54535458 - 54537458GSE27584


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