Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

7184

Name

HSP90B1

Synonymous

ECGP|GP96|GRP94|HEL-S-125m|HEL35|TRA1;heat shock protein 90kDa beta (Grp94), member 1;HSP90B1;heat shock protein 90kDa beta (Grp94), member 1

Definition

94 kDa glucose-regulated protein|endoplasmin|endothelial cell (HBMEC) glycoprotein|epididymis luminal protein 35|epididymis secretory sperm binding protein Li 125m|heat shock protein 90 kDa beta member 1|stress-inducible tumor rejection antigen gp96|tumor

Position

12q24.2-q24.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

Grp94(h) + AIMP1(m.s.) <==> Grp94(h):AIMP1(m.s.) (binding)
Grp94(h) + Grp94(m.s.) <==> Grp94(h):Grp94(m.s.) (binding; oligomerization)
HSP90B1(h) --> Grp94(h) (expression).
Grp94(h) + AR(h) <==> Grp94(h):AR(h) (binding)
ErbB2(h) + Grp94(h) <==> ErbB2(h):Grp94(h) (binding)
Grp94(h) + AIMP1(h) <==> Grp94(h):AIMP1(h) (binding)
Grp94(h) + AIMP1(m.s.) <==> Grp94(h):AIMP1(m.s.) (binding)
HSP90B1(h) --> Grp94(h) (expression).
HCV-core-1B(HCV1B) --> Grp94(h) (increase of abundance)

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

62N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
107N-linked (GlcNAc...).Swiss-Prot 53.0
217N-linked (GlcNAc...).Swiss-Prot 53.0
445N-linked (GlcNAc...).Swiss-Prot 53.0
481N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
502N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0

Methylation Profile   [Top]

Chromosome

Location

Source

chr12

Promoter: 102846819 - 102848819GSE27584

chr12

Promoter: 102846819 - 102848819Agilent_014791_44K


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