| General information | Literature | Expression | Regulation | Variant | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 7422 |
Name | VEGFA |
Synonymous | MVCD1|VEGF|VPF;vascular endothelial growth factor A;VEGFA;vascular endothelial growth factor A |
Definition | vascular permeability factor |
Position | 6p12 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] | |||
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Transcription Factors [Top] |
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Regulation From TransFac database |
VEGF-165(h) + NP-1(h) <==> VEGF-165(h):NP-1(h) (binding) | VEGF-165(h) + VEGFR-2(h) <==> VEGF-165(h):VEGFR-2(h) (binding) | VEGF-165(h) + NP-1(m) <==> VEGF-165(h):NP-1(m) (binding) | VEGF-165(h) + neuropilin2(h) <==> VEGF-165(h):neuropilin2(h) (binding) | VEGF-165(h) + Abeta42(m.s.) <==> VEGF-165(h):Abeta42(m.s.) (binding) | VEGF-165(h) + ADAMTS-1(h) <==> VEGF-165(h):ADAMTS-1(h) (binding) | VEGF-165(h) --> VEGFR-2(h){pY} (increase of phosphorylation) | VEGF-165(h) --> AKT-1(h){pS473} (increase of phosphorylation) | VEGF-165(h) --> ERK(h){p} (increase of phosphorylation) | VEGF-165(h) --> JNK(h){p} (increase of phosphorylation) | VEGF-165(h) --> FOXO1A(h){pS256} (increase of phosphorylation) | VEGF-165(h) --> p38(h){p} (increase of phosphorylation) | VEGF-165(h) --> Src(h){pY416} (increase of phosphorylation) | VEGF-165(h) --> FAK1(h){pY861}{pY925} (increase of phosphorylation) | VEGF-165(h) --> PLCgamma1(h){p} (increase of phosphorylation) | VEGF-165(h) --> ACE(h) (transactivation) | VEGF-165(h) --> ADAMTS9(h) (transactivation) | VEGF-165(h) --> MGP(h) (transactivation) | VEGF-165(h) --> ESM1(h) (transactivation) | VEGF-165(h) --> HMOX1(h) (transactivation) | VEGF-165(h) --> SOD2(h) (transactivation) | VEGF-165(h) --> INSR(h) (transactivation) | VEGF-165(h) --> Pdgfd(h) (transactivation) | VEGF-165(h) --> PCDH12(h) (transactivation) | VEGF-165(h) --> SELE(h) (transactivation) | VEGF-165(h) --> Vcam1(m) (transactivation) | VEGF-165(h) --> PMCH(h) (transactivation) | VEGF-165(h) --> THBD(h) (transactivation) | VEGF-165(h) --> UBE2J1(h) (transactivation) | VEGF-165(h) --/ ADFP(h) (transrepression) | VEGF-165(h) --/ BTG1(h) (transrepression) | VEGF-165(h) --/ CDKN1B(h) (transrepression) | VEGF-165(h) --/ GADD45A(h) (transrepression) | VEGF-165(h) --/ GADD45B(h) (transrepression) | VEGF-165(h) --/ CASP8(h) (transrepression) | VEGF-165(h) --/ INPP5D(h) (transrepression) | VEGF-165(h) --/ MAP2K7(h) (transrepression) | VEGF-165(h) --/ NFIB(h) (transrepression) | VEGF-165(h) --/ THSD1(h) (transrepression) | VEGF-165(h) --/ TNFRSF1B(h) (transrepression) | VEGF-165(h) --/ TNFSF10(h) (transrepression) | VEGF-165(h) --/ TXNIP(h) (transrepression) | VEGF-165(h) --> BMP2(h) (transactivation) | VEGF-165(h) --> RCAN1(h) (transactivation) | VEGF-165(h) --> PDGFA(h) (transactivation) | VEGF-165(h) --> VEGFC(h) (transactivation) | VEGF-165(h) --> EGR1(h) (transactivation) | VEGF-165(h) --> KLF5(h) (transactivation) | VEGF-165(h) --> ICAM1(h) (transactivation) | VEGF-165(h) --> SERPINE1(h) (transactivation) | VEGF-165(h) --> tPA(h) (transactivation) | VEGF-165(h) --> SPRY4(h) (transactivation) | VEGF-165(h) --> CD55(h) (transactivation) | VEGF-165(h) --> VEGFR-2(h){pY951}{pY1175} (increase of phosphorylation) | VEGFA(h) --> VEGF-165(h) (expression). | RPB7(h) --> VEGF-A(h) (increase of secretion; increase of promoter activity) | brca1(h) --> VEGF-A(h) (increase of secretion) | brca1(h) --> VEGF-A(h) (decrease of secretion) | VEGFA(h) --> VEGF-A(h) (expression). | angiotensin II(h) --> VEGF-A(h) (increase of abundance) | Nod2(m.s.) --> VEGF-A(h) (increase of abundance) | TNF-alpha(h) --> VEGF-A(h) (increase of secretion) | IL-1alpha(h) --> VEGF-A(h) (increase of secretion) | IL-1beta(h) --> VEGF-A(h) (increase of secretion) | IFNgamma(h) --> VEGF-A(h) (decrease of secretion) | TGFbeta1(m.s.) --> VEGF-A(h) (increase of secretion) | TGFbeta2(m.s.) --> VEGF-A(h) (increase of secretion) | HGF(h) --> VEGF-A(h) (increase of abundance) | VEGF-145(h) + neuropilin2(h) <==> VEGF-145(h):neuropilin2(h) (binding) | VEGFA(h) --> VEGF-145(h) (expression). | VEGFA(h) --> VEGF-189(h) (expression). | VEGFA(h) --> VEGF-148(h) (expression). | VEGFA(h) --> VEGF-165b(h) (expression). | VEGFA(h) --> VEGF_1(h) (expression). | VEGFA(h) --> VEGF_2(h) (expression). | VEGFA(h) --> VEGF_3(h) (expression). | VEGFA(h) --> VEGF_4(h) (expression). | VEGFA(h) --> VEGF_5(h) (expression). | VEGFA(h) --> VEGF_6(h) (expression). | hsa-miR-125a --/ VEGF_6(h) (translational repression). | hsa-miR-93 --/ VEGF_6(h) (translational repression). | hsa-miR-302d --/ VEGF_6(h) (translational repression). | hsa-miR-373 --/ VEGF_6(h) (translational repression). | hsa-miR-378 --/ VEGF_6(h) (translational repression). | hsa-miR-16 --/ VEGF_6(h) (translational repression). | VEGFA(h) --> VEGF_7(h) (expression). | VEGFA(h) --> VEGF-206(h) (expression). | VEGFA(h) --> VEGF-183(h) (expression). |
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Post Transcriptional Modification [Top] | |||
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Location (AA) |
PTM type |
Literature |
Database |
101 | N-linked (GlcNAc...). | Swiss-Prot 53.0 | 147 | N6-acetyllysine. | Swiss-Prot 53.0 | 149 | N6-acetyllysine. | Swiss-Prot 53.0 | 152 | N6-acetyllysine. | Swiss-Prot 53.0 |
|---|---|---|---|
Methylation Profile [Top] | ||
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Chromosome |
Location |
Source |
|---|---|---|
chr6 |
Promoter: 43844431 - 43846431 | GSE27584 |
chr6 |
Promoter: 43844431 - 43846431 | GSE27584 |
chr6 |
Promoter: 43844431 - 43846431 | GSE27584 |
chr6 |
Promoter: 43844431 - 43846431 | GSE27584 |
chr6 |
Promoter: 43844431 - 43846431 | GSE27584 |
chr6 |
Promoter: 43844431 - 43846431 | GSE27584 |
chr6 |
Promoter: 43844431 - 43846431 | GSE27584 |
chr6 |
Promoter: 43844431 - 43846431 | Agilent_014791_44K |
chr6 |
Promoter: 43844431 - 43846431 | Agilent_014791 |