Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Variant | Interaction

Basic Information

Gene ID

9046

Name

DOK2

Synonymous

p56DOK|p56dok-2;docking protein 2, 56kDa;DOK2;docking protein 2, 56kDa

Definition

docking protein 2|docking protein 2, 56kD|downstream of tyrosine kinase 2|p56(dok-2)

Position

8p21.3

Gene Type

protein-coding

Gene Regulation:

Upstream microRNAs
Transcription Factors
Post Transcriptional Modification From dbPTM
Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase   [Top]

Experimentally validated miRNA-TS gene regulation information.

Transcription Factors   [Top]

Regulation From TransFac database

psmd10(h) + p56Dok-2(h) <==> psmd10(h):p56Dok-2(h) (binding)
SSSCA1(h) + p56Dok-2(h) <==> SSSCA1(h):p56Dok-2(h) (binding)
p56Dok-2(h) + APG1(h) <==> p56Dok-2(h):APG1(h) (binding)
p56Dok-2(h) + rab10(h) <==> p56Dok-2(h):rab10(h) (binding)
CIA-II(h) + p56Dok-2(h) <==> CIA-II(h):p56Dok-2(h) (binding)
SPOP(h) + p56Dok-2(h) <==> SPOP(h):p56Dok-2(h) (binding)
p56Dok-2(h) + DNAJB11(h) <==> p56Dok-2(h):DNAJB11(h) (binding)
c-FLIP(h) + p56Dok-2(h) <==> c-FLIP(h):p56Dok-2(h) (binding)
p56Dok-2(h) + KBP(h) <==> p56Dok-2(h):KBP(h) (binding)
p56Dok-2(h) + ATP --> p56Dok-2(h){pY} + ADP (phosphorylation)
LAT(h) + p56Dok-2(h) + SHIP(h) + Grb-2(h) <==> LAT(h):p56Dok-2(h):SHIP(h):Grb-2(h) (binding)
p56Dok-2(h) + ATP --> p56Dok-2(h){pY345} + ADP (phosphorylation)
p56Dok-2(h) + SHIP(h){pY} <==> p56Dok-2(h):SHIP(h){pY} (binding)
SHIP(h){pY} + p56Dok-2(h) + p62Dok-1(h) <==> SHIP(h){pY}:p56Dok-2(h):p62Dok-1(h) (binding)
DOK2(h) --> p56Dok-2(h) (expression).
ErbB1-p170(h) + p56Dok-2(h) <==> p56Dok-2(h):ErbB1-p170(h) (binding)
DOK2(h) --> p56Dok-2(h) (expression).

Post Transcriptional Modification   [Top]

Location (AA)

PTM type

Literature

Database

271Phosphotyrosine (By similarity).Swiss-Prot 53.0
299Phosphotyrosine.Swiss-Prot 53.0
345Phosphotyrosine (By similarity).Swiss-Prot 53.0
271Phosphotyrosine10508618Phospho.ELM 6.0
299Phosphotyrosine10508618;12522270;15144186;15592455;16094384Phospho.ELM 6.0
345Phosphotyrosine11689432;9764820Phospho.ELM 6.0
139Phosphotyrosine16497976Phospho.ELM 6.0

Methylation Profile   [Top]

There is no record for DOK2



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