Entrez Gene

Basic Information
Gene ID	9113
Name	LATS1
Synonymous	WARTS\|wts;large tumor suppressor kinase 1;LATS1;large tumor suppressor kinase 1
Definition	LATS (large tumor suppressor, Drosophila) homolog 1\|LATS, large tumor suppressor, homolog 1\|WARTS protein kinase\|h-warts\|large tumor suppressor homolog 1\|serine/threonine-protein kinase LATS1
Position	6q25.1
Gene Type	protein-coding
Gene Regulation:	Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database

Experimentally verified miRNA from miRTarBase [Top]

Regulation From TransFac database
Transcription Factors [Top]
Lats1(h) + ATP --cyclinB(h):Cdk1(h)--> Lats1(h){pS613} + ADP (phosphorylation)
cyclinB(h):Cdk1(h) + Lats1(h) <==> cyclinB(h):Cdk1(h):Lats1(h) (binding)
Lats1(h) + zyxin(h){p} <==> Lats1(h):zyxin(h){p} (binding)
sav1(h) + RASSF1-A(h) + MST2(h) + Lats1(h) <==> sav1(h):RASSF1-A(h):MST2(h):Lats1(h) (binding)
MOB1A(h) + Lats1(h) <==> MOB1A(h):Lats1(h) (binding)
LATS1(h) --> Lats1(h) (expression).
MOB1A(h) + Lats1(h) <==> MOB1A(h):Lats1(h) (binding)
MOB1A(h) + Lats1(h) <==> MOB1A(h):Lats1(h) (binding)
LATS1(h) --> Lats1(h) (expression).

Location (AA)	PTM type	Literature	Database
Post Transcriptional Modification [Top]
244	Phosphoserine.		Swiss-Prot 53.0
464	Phosphoserine (By similarity).		Swiss-Prot 53.0
909	Phosphoserine (by STK3).		Swiss-Prot 53.0
1079	Phosphothreonine (by STK3).		Swiss-Prot 53.0
244	Phosphoserine	15302935	Phospho.ELM 6.0
464	Phosphoserine	15302935	Phospho.ELM 6.0
1079	Phosphothreonine	15688006	Phospho.ELM 6.0
613	Phosphoserine	15688006	Phospho.ELM 6.0
909	Phosphoserine	15688006	Phospho.ELM 6.0
633	Phosphoserine	15688006	Phospho.ELM 6.0
1111	Phosphoserine	15688006	Phospho.ELM 6.0