General information | Literature | Expression | Regulation | Variant | Interaction |
Basic Information |
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Gene ID | 9113 |
Name | LATS1 |
Synonymous | WARTS|wts;large tumor suppressor kinase 1;LATS1;large tumor suppressor kinase 1 |
Definition | LATS (large tumor suppressor, Drosophila) homolog 1|LATS, large tumor suppressor, homolog 1|WARTS protein kinase|h-warts|large tumor suppressor homolog 1|serine/threonine-protein kinase LATS1 |
Position | 6q25.1 |
Gene Type | protein-coding |
Gene Regulation: | Upstream microRNAs Transcription Factors Post Transcriptional Modification From dbPTM Methylation Profile From DiseaseMeth database |
Experimentally verified miRNA from miRTarBase [Top] |
Transcription Factors [Top] |
Regulation From TransFac database |
Lats1(h) + ATP --cyclinB(h):Cdk1(h)--> Lats1(h){pS613} + ADP (phosphorylation) | cyclinB(h):Cdk1(h) + Lats1(h) <==> cyclinB(h):Cdk1(h):Lats1(h) (binding) | Lats1(h) + zyxin(h){p} <==> Lats1(h):zyxin(h){p} (binding) | sav1(h) + RASSF1-A(h) + MST2(h) + Lats1(h) <==> sav1(h):RASSF1-A(h):MST2(h):Lats1(h) (binding) | MOB1A(h) + Lats1(h) <==> MOB1A(h):Lats1(h) (binding) | LATS1(h) --> Lats1(h) (expression). | MOB1A(h) + Lats1(h) <==> MOB1A(h):Lats1(h) (binding) | MOB1A(h) + Lats1(h) <==> MOB1A(h):Lats1(h) (binding) | LATS1(h) --> Lats1(h) (expression). |
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Post Transcriptional Modification [Top] | |||
Location (AA) |
PTM type |
Literature |
Database |
244 | Phosphoserine. | Swiss-Prot 53.0 | 464 | Phosphoserine (By similarity). | Swiss-Prot 53.0 | 909 | Phosphoserine (by STK3). | Swiss-Prot 53.0 | 1079 | Phosphothreonine (by STK3). | Swiss-Prot 53.0 | 244 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 464 | Phosphoserine | 15302935 | Phospho.ELM 6.0 | 1079 | Phosphothreonine | 15688006 | Phospho.ELM 6.0 | 613 | Phosphoserine | 15688006 | Phospho.ELM 6.0 | 909 | Phosphoserine | 15688006 | Phospho.ELM 6.0 | 633 | Phosphoserine | 15688006 | Phospho.ELM 6.0 | 1111 | Phosphoserine | 15688006 | Phospho.ELM 6.0 |
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Methylation Profile [Top] | ||
Chromosome |
Location |
Source |
---|---|---|
chr6 |
Promoter: 150080585 - 150082585 | Agilent_014791 |
chr6 |
Promoter: 150080585 - 150082585 | GSE27584 |
chr6 |
Promoter: 150080585 - 150082585 | Agilent_014791_44K |
chr6 |
Promoter: 150080585 - 150082585 | PMID:15198948 |
chr6 |
Promoter: 150080585 - 150082585 | PMID:16192589 |
chr6 |
Promoter: 150080585 - 150082585 | PMID:15746036 |
chr6 |
Promoter: 150080585 - 150082585 | PMID:17049657 |