| General information | Literature | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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Gene ID | 51201 |
Name | ZDHHC2 |
Synonymous | DHHC2|ZNF372;zinc finger, DHHC-type containing 2;ZDHHC2;zinc finger, DHHC-type containing 2 |
Definition | DHHC-2|palmitoyltransferase ZDHHC2|ream|rec|reduced expression associated with metastasis protein|reduced expression in cancer protein|zinc finger DHHC domain-containing protein 2|zinc finger protein 372|zinc finger, DHHC domain containing 2 |
Position | 8p22 |
Gene type | protein-coding |
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Title |
Abstract |
| Identification of CKAP4/p63 as a major substrate of the palmitoyl acyltransferase DHHC2, a putative tumor suppressor, using a novel proteomics method. | Protein palmitoylation is the post-translational addition of the 16-carbon fatty acid palmitate to specific cysteine residues by a labile thioester linkage. Palmitoylation is mediated by a family of at least 23 palmitoyl acyltransferases (PATs) characterized by an Asp-His-His-Cys (DHHC) motif. Many palmitoylated proteins have been identified, but PAT-substrate relationships are mostly unknown. Here we present a method called palmitoyl-cysteine isolation capture and analysis (or PICA) to identify PAT-substrate relationships in a living vertebrate system and demonstrate its effectiveness by identifying CKAP4/p63 as a substrate of DHHC2, a putative tumor suppressor. |