| General information | Literature | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 54802 |
Name | TRIT1 |
Synonymous | IPT|MOD5;tRNA isopentenyltransferase 1;TRIT1;tRNA isopentenyltransferase 1 |
Definition | IPP transferase|IPPT|IPTase|hGRO1|isopentenyl-diphosphate:tRNA isopentenyltransferase|tRNA dimethylallyltransferase, mitochondrial|tRNA isopentenylpyrophosphate transferase |
Position | 1p34.2 |
Gene type | protein-coding |
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Title |
Abstract |
| The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer. | Mod5 is the yeast tRNA isopentenyl transferase, an enzyme that is conserved from bacteria to humans. Mod5 is primarily cytoplasmic where it modifies the A37 position of a few tRNAs, and the yeast enzyme has been shown capable of forming heritable, amyloid-like aggregates that confer a selective advantage in the presence of specific antifungal agents. A subpopulation of Mod5 is also found associated with nuclear tRNA genes, where it contributes tRNA-gene mediated (tgm) silencing of local transcription by RNA polymerase II. The tgm-silencing function of Mod5 has been observed in yeast and a Mod5-deletion in yeast can be complemented by the plant and human tRNA isopentenyl transferases, but not the bacterial enzymes, possibly due to the lack of an extended C-terminal domain found in eukaryotes. In light of this additional nuclear role for Mod5 we discuss the proposed role of the human homologue of Mod5, TRIT1, as a tumor suppressor protein. |