| General information | Literature | Expression | Regulation | Mutation | Interaction |
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Basic Information |
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|---|---|
Gene ID | 6297 |
Name | SALL2 |
Synonymous | COLB|HSAL2|Sal-2|ZNF795|p150(Sal2);spalt-like transcription factor 2;SALL2;spalt-like transcription factor 2 |
Definition | sal-like protein 2|zinc finger protein 795|zinc finger protein SALL2|zinc finger protein Spalt-2 |
Position | 14q11.1-q12 |
Gene type | protein-coding |
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Title |
Abstract |
| The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC. | p150, product of the SALL2 gene, is a binding partner of the polyoma virus large T antigen and a putative tumor suppressor. p150 binds to the nuclease hypersensitive element of the c-MYC promoter and represses c-MYC transcription. Overexpression of p150 in human ovarian surface epithelial cells leads to decreased expression, and downregulation to increased expression, of c-MYC. c-MYC is repressed upon restoration of p150 to ovarian carcinoma cells. Induction of apoptosis by etoposide results in recruitment of p150 to the c-MYC promoter and to repression of c-MYC. Analysis of data in The cancer Genome Atlas shows negative correlations between SALL2 and c-MYC expression in four common solid tumor types. |