| General information | Literature | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
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|---|---|
Gene ID | 8726 |
Name | EED |
Synonymous | HEED|WAIT1;embryonic ectoderm development;EED;embryonic ectoderm development |
Definition | WD protein associating with integrin cytoplasmic tails 1|polycomb protein EED |
Position | 11q14.2-q22.3 |
Gene type | protein-coding |
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Title |
Abstract |
| Polycomb repressive complex 2 (PRC2) suppresses Emu-myc lymphoma. | Deregulation of polycomb group complexes polycomb repressive complex 1 (PRC1) and 2 (PRC2) is associated with human cancers. Although inactivating mutations in PRC2-encoding genes EZH2, EED, and SUZ12 are present in T-cell acute lymphoblastic leukemia and in myeloid malignancies, gain-of-function mutations in EZH2 are frequently observed in B-cell lymphoma, implying disease-dependent effects of individual mutations. We show that, in contrast to PRC1, PRC2 is a tumor suppressor in Emicro-myc lymphomagenesis, because disease onset was accelerated by heterozygosity for Suz12 or by short hairpin RNA-mediated knockdown of Suz12 or Ezh2. Accelerated lymphomagenesis was associated with increased accumulation of B-lymphoid cells in the absence of effects on apoptosis or cell cycling. However, Suz12-deficient B-lymphoid progenitors exhibit enhanced serial clonogenicity. Thus, PRC2 normally restricts the self-renewal of B-lymphoid progenitors, the disruption of which contributes to lymphomagenesis. This finding provides new insight regarding the functional contribution of mutations in PRC2 in a range of leukemias. |