| General information | Literature | Expression | Regulation | Mutation | Interaction |
|
Basic Information |
|
|---|---|
Gene ID | 9455 |
Name | HOMER2 |
Synonymous | ACPD|CPD|HOMER-2|VESL-2;homer scaffolding protein 2;HOMER2;homer scaffolding protein 2 |
Definition | cupidin|homer homolog 2|homer homolog 3|homer protein homolog 2|homer, neuronal immediate early gene, 2 |
Position | 15q24.3 |
Gene type | protein-coding |
|
Title |
Abstract |
| HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth. | MYO18B is a class XVIII myosin, cloned as a tumor suppressor gene candidate. To investigate the mechanisms of MYO18B-dependent tumor suppression, MYO18B-interacting proteins were searched for by a yeast two-hybrid screen. HOMER2, a Homer/Ves1 family protein, was identified as a binding partner of MYO18B. These proteins co-localized in the regions of membrane protrusion and stress fiber, which are known as ones with filamentous actin-rich structures. expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression. |