Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
bioinfom_tsdb
Pulmonary Arterial Hypertension KnowledgeBase
General information | Literature | Expression | Regulation | Mutation | Interaction

Basic Information

Gene ID

9455

Name

HOMER2

Synonymous

ACPD|CPD|HOMER-2|VESL-2;homer scaffolding protein 2;HOMER2;homer scaffolding protein 2

Definition

cupidin|homer homolog 2|homer homolog 3|homer protein homolog 2|homer, neuronal immediate early gene, 2

Position

15q24.3

Gene type

protein-coding

Title

Abstract

HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth.

MYO18B is a class XVIII myosin, cloned as a tumor suppressor gene candidate. To investigate the mechanisms of MYO18B-dependent tumor suppression, MYO18B-interacting proteins were searched for by a yeast two-hybrid screen. HOMER2, a Homer/Ves1 family protein, was identified as a binding partner of MYO18B. These proteins co-localized in the regions of membrane protrusion and stress fiber, which are known as ones with filamentous actin-rich structures. expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression.

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