Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	10078
Name	TSSC4
Synonymous	-;tumor suppressing subtransferable candidate 4;TSSC4;tumor suppressing subtransferable candidate 4
Definition	protein TSSC4\|tumor-suppressing STF cDNA 4 protein\|tumor-suppressing subchromosomal transferable fragment candidate gene 4 protein
Position	11p15.5
Gene type	protein-coding
Source	Count: 2; TAG,Generif
Sentence	Abstract
"This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region."	We previously reported the isolation of a 2.5 Mb tumor-suppressing subchromosomal transferable fragment (STF) from human chromosome 11p15 and the identification of nine known genes and four novel genes within this STF. We now report the isolation of two novel cDNAs, designated here as TSSC4 and TSSC6 (tumor-suppressing STF cDNA 4 and 6), located within the STF. TSSC4 and TSSC6 encode predicted proteins of 329 and 290 amino acids, respectively, with no close similarity to previously reported proteins. TSSC4 and TSSC6 are both located in the center of a 1 Mb imprinted domain, which contains the imprinted genes TSSC3, TSSC5, p57(KIP2), KVLQT1, ASCL2, IGF2 and H19. However, we found that neither TSSC4 nor TSSC6 was significantly imprinted in any of the fetal or extra-embryonic tissues examined. Based on this result, the imprinted gene domain of 11p15 appears to contain at least two imprinted subdomains, between which TSSC4 and TSSC6 substantially escape imprinting, due either to lack of initial silencing or to an early developmental relaxation of imprinting.