Entrez Gene

Basic Information
Gene ID	121227
Name	LRIG3
Synonymous	LIG3;leucine-rich repeats and immunoglobulin-like domains 3;LRIG3;leucine-rich repeats and immunoglobulin-like domains 3
Definition	LIG-3\|leucine-rich repeats and immunoglobulin-like domains protein 3
Position	12q14.1
Gene type	protein-coding
Source	Count: 1; Generif
Sentence	Abstract
"LRIG3 may be involved in the regulation of EGF receptor signaling, and serve as a tumor suppressor gene in the pathogenesis of glioma."	LRIG3 (leucine-rich repeats and immunoglobulin-like domains, LRIG) gene is both under-and over-expressed in human cancers and its role on tumor growth is not fully clarified. Here, we used a human U6 promoter-driven DNA template approach to induce short hairpin RNA (shRNA)-triggered RNA interference (RNAi) to block LRIG3 gene expression in the human glioma cell line GL15. Specific knockdown of LRIG3 by shRNA resulted in significantly increase of the GL15 invasion and adhesion activity in vitro and markedly promoted cell growth. LRIG3 repression also induced increment of the proportion of G0/G1 cells and inhibited apoptosis in GL15 cells. Our results demonstrated that RNAi against LRIG3 could effectively down regulate LRIG3 gene expression. LRIG3 might be involved in the regulation of EGFR signaling, and serve as a tumor suppressor gene in the pathogenesis of glioma.