Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	2189
Name	FANCG
Synonymous	FAG\|XRCC9;Fanconi anemia, complementation group G;FANCG;Fanconi anemia, complementation group G
Definition	DNA repair protein XRCC9\|Fanconi anemia group G protein\|X-ray repair complementing defective repair in Chinese hamster cells 9\|X-ray repair, complementing defective, in Chinese hamster, 9
Position	9p13
Gene type	protein-coding
Source	Count: 2; TAG,Generif
Sentence	Abstract
"Finally, five novel minimally deleted regions were identified in a subset of tumors, containing putative candidate tumor suppressor genes (TOPORS, FANCG, RAD51, TP53BP1, and BIK) that could have a role in gliomagenesis."	High-resolution genome-wide mapping of exact boundaries of chromosomal alterations should facilitate the localization and identification of genes involved in gliomagenesis and may characterize genetic subgroups of glial brain tumors. We have done such mapping using cDNA microarray-based comparative genomic hybridization technology to profile copy number alterations across 42,000 mapped human cDNA clones, in a series of 54 gliomas of varying histogenesis and tumor grade. This gene-by-gene approach permitted the precise sizing of critical amplicons and deletions and the detection of multiple new genetic aberrations. It has also revealed recurrent patterns of occurrence of distinct chromosomal aberrations as well as their interrelationships and showed that gliomas can be clustered into distinct genetic subgroups. A subset of detected alterations was shown predominantly associated with either astrocytic or oligodendrocytic tumor phenotype. Finally, five novel minimally deleted regions were identified in a subset of tumors, containing putative candidate tumor suppressor genes (TOPORS, FANCG, RAD51, TP53BP1, and BIK) that could have a role in gliomagenesis.