Entrez Gene

Basic Information
Gene ID	2296
Name	FOXC1
Synonymous	ARA\|FKHL7\|FREAC-3\|FREAC3\|IGDA\|IHG1\|IRID1\|RIEG3;forkhead box C1;FOXC1;forkhead box C1
Definition	forkhead box protein C1\|forkhead, drosophila, homolog-like 7\|forkhead-related activator 3\|forkhead-related protein FKHL7\|forkhead-related transcription factor 3\|forkhead/winged helix-like transcription factor 7\|myeloid factor-delta
Position	6p25
Gene type	protein-coding
Source	Count: 1; Generif
Sentence	Abstract
FOXC1 functions as a tumor suppressor through TGF-beta1 mediated signals.	We cloned the forkhead box C1 (FOXC1) gene, a member of the forkhead/winged-helix transcription factor family, as a transforming growth factor-beta1 (TGF-beta1) responsive gene. We showed that TGF-beta1 upregulated transcription of FOXC1 in several human cancer cell lines. Ectopic expression of FOXC1 cDNA in HeLa cells, which lack both copies of the FOXC1 allele, restores the potential of TGF-beta1 to inhibit cell growth by arresting cells in the G0/G1 phase. In addition, screens of primary endometrial and ovarian cancers revealed homozygous deletion of FOXC1 in 6.7% of them, one nonsense and one missense mutation of FOXC1, and transcriptional silencing in 11.7% of primary cancers. Evidence that a significant fraction of primary cancers exhibited somatic mutations suggests that FOXC1 functions as a tumor suppressor through TGF-beta1 mediated signals.