Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	26047
Name	CNTNAP2
Synonymous	AUTS15\|CASPR2\|CDFE\|NRXN4\|PTHSL1;contactin associated protein-like 2;CNTNAP2;contactin associated protein-like 2
Definition	cell recognition molecule Caspr2\|contactin-associated protein 2\|contactin-associated protein-like 2\|homolog of Drosophila neurexin IV
Position	7q35
Gene type	protein-coding
Source	Count: 1; Generif
Sentence	Abstract
CASPR2 acts as a tumor suppressor gene in glioma.	Genomic translocations have been implicated in cancer. In this study, we performed a screen for genetic translocations in gliomas based on exon-level expression profiles. We identified a translocation in the contactin-associated protein-like 2 (CASPR2) gene, encoding a cell adhesion molecule. CASPR2 mRNA was fused to an expressed sequence tag that likely is part of the nuclear receptor coactivator 1 gene. Despite high mRNA expression levels, no CASPR2 fusion protein was detected. In a set of 25 glioblastomas and 22 oligodendrogliomas, mutation analysis identified two additional samples with genetic alterations in the CASPR2 gene and all three identified genetic alterations are likely to reduce CASPR2 protein expression levels. Methylation of the CASPR2 gene was also observed in gliomas and glioma cell lines. CASPR2-overexpressing cells showed decreased proliferation rates, likely because of an increase in apoptosis. Moreover, high CASPR2 mRNA expression level is positively correlated with survival and is an independent prognostic factor. These results indicate that CASPR2 acts as a tumor suppressor gene in glioma.