Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	57491
Name	AHRR
Synonymous	AHH\|AHHR\|bHLHe77;aryl-hydrocarbon receptor repressor;AHRR;aryl-hydrocarbon receptor repressor
Definition	ahR repressor\|aryl hydrocarbon hydroxylase regulator\|aryl hydrocarbon receptor repressor\|class E basic helix-loop-helix protein 77\|dioxin receptor repressor
Position	5p15.3
Gene type	protein-coding
Source	Count: 1; Generif
Sentence	Abstract
These results therefore demonstrate that AHRR is a putative new tumor suppressor gene in multiple types of human cancers.	The aryl hydrocarbon receptor repressor (AHRR) is a bHLH/Per-ARNT-Sim transcription factor located in a region of chromosome 5 (5p15.3) that has been proposed to contain one or more tumor suppressor genes. We report here consistent downregulation of AHRR mRNA in human malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary, and demonstrate DNA hypermethylation as the regulatory mechanism of AHRR gene silencing. Knockdown of AHRR gene expression in a human lung cancer cell line using siRNA significantly enhanced in vitro anchorage-dependent and -independent cell growth as well as cell growth after transplantation into immunocompromised mice. In addition, knockdown of AHRR in non-clonable normal human mammary epithelial cells enabled them to grow in an anchorage-independent manner. Further, downregulation of AHRR expression in the human lung cancer cell line conferred resistance to apoptotic signals and enhanced motility and invasion in vitro and angiogenic potential in vivo. Ectopic expression of AHRR in tumor cells resulted in diminished anchorage-dependent and -independent cell growth and reduced angiogenic potential. These results therefore demonstrate that AHRR is a putative new tumor suppressor gene in multiple types of human cancers.