Entrez Gene

Basic Information
Gene ID	83787
Name	ARMC10
Synonymous	PNAS-112\|PNAS112\|SVH;armadillo repeat containing 10;ARMC10;armadillo repeat containing 10
Definition	armadillo repeat-containing protein 10\|specific splicing variant involved in hepatocarcinogenesis\|splicing variant involved in hepatocarcinogenesis protein
Position	7q22.1
Gene type	protein-coding
Source	Count: 2; TAG,Generif
Sentence	Abstract
"We have extensively characterized the FBXL13, NAPE-PLD, and SVH genes as candidate myeloid tumor suppressors."	Monosomy 7 and deletions of 7q are recurring leukemia-associated cytogenetic abnormalities that correlate with adverse outcomes in children and adults. We describe a 2.52-Mb genomic DNA contig that spans a commonly deleted segment of chromosome band 7q22 identified in myeloid malignancies. This interval currently includes 14 genes, 19 predicted genes, and 5 predicted pseudogenes. We have extensively characterized the FBXL13, NAPE-PLD, and SVH genes as candidate myeloid tumor suppressors. FBXL13 encodes a novel F-box protein, SVHis a member of a gene family that contains Armadillo-like repeats, and NAPE-PLD encodes a phospholipase D-type phosphodiesterase. Analysis of a panel of leukemia specimens with monosomy 7 did not reveal mutations in these or in the candidate genes LRRC17, PRO1598, and SRPK2. This fully sequenced and annotated contig provides a resource for candidate myeloid tumor suppressor gene discovery.