Entrez Gene

General information | Expression | Regulation | Mutation | Interaction

Basic Information
Gene ID	8805
Name	TRIM24
Synonymous	PTC6\|RNF82\|TF1A\|TIF1\|TIF1A\|TIF1ALPHA\|hTIF1;tripartite motif containing 24;TRIM24;tripartite motif containing 24
Definition	E3 ubiquitin-protein ligase TRIM24\|RING finger protein 82\|TIF1-alpha\|transcription intermediary factor 1-alpha\|transcriptional intermediary factor 1\|tripartite motif-containing 24
Position	7q32-q34
Gene type	protein-coding
Source	Count: 2; Generif,UniProt
Sentence	Abstract
Tripartite motif 24 (Trim24/Tif1?) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor ? (Rar?) inhibition.	Recent genetic studies in mice have established that the nuclear receptor coregulator Trim24/Tif1alpha suppresses hepatocarcinogenesis by inhibiting retinoic acid receptor alpha (Rara)-dependent transcription and cell proliferation. However, Rara targets regulated by Trim24 remain unknown. We report that the loss of Trim24 resulted in interferon (IFN)/STAT pathway overactivation soon after birth (week 5). Despite a transient attenuation of this pathway by the induction of several IFN/STAT pathway repressors later in the disease, this phenomenon became more pronounced in tumors. Remarkably, Rara haplodeficiency, which suppresses tumorigenesis in Trim24(-/-) mice, prevented IFN/STAT overactivation. Moreover, together with Rara, Trim24 bound to the retinoic acid-responsive element of the Stat1 promoter and repressed its retinoic acid-induced transcription. Altogether, these results identify Trim24 as a novel negative regulator of the IFN/STAT pathway and suggest that this repression through Rara inhibition may prevent liver cancer.