| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30080752 | HIV | ENSG00000197122.13 | protein_coding | SRC | Yes | No | 6714 | P12931 |
| TVIS30081124 | HIV | ENSG00000197122.13 | protein_coding | SRC | Yes | No | 6714 | P12931 |
| TVIS30020612 | HIV | ENSG00000197122.13 | protein_coding | SRC | Yes | No | 6714 | P12931 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
| Gene | SRC |
|---|---|
| DrugBank ID | DB01254 |
| Drug Name | Dasatinib |
| Target ID | BE0000838 |
| UniProt ID | P12931 |
| Regulation Type | inhibitor |
| PubMed IDs | 17429625; 17148760; 17155893; 16397263; 16230377 |
| Citations | Kamath AV, Wang J, Lee FY, Marathe PH: Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABL. Cancer Chemother Pharmacol. 2008 Mar;61(3):365-76. Epub 2007 Apr 11.@@Serrels A, Macpherson IR, Evans TR, Lee FY, Clark EA, Sansom OJ, Ashton GH, Frame MC, Brunton VG: Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther. 2006 Dec;5(12):3014-22. Epub 2006 Dec 5.@@Quintas-Cardama A, Kantarjian H, Cortes J: Targeting ABL and SRC kinases in chronic myeloid leukemia: experience with dasatinib. Future Oncol. 2006 Dec;2(6):655-65.@@Schittenhelm MM, Shiraga S, Schroeder A, Corbin AS, Griffith D, Lee FY, Bokemeyer C, Deininger MW, Druker BJ, Heinrich MC: Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res. 2006 Jan 1;66(1):473-81.@@Nam S, Kim D, Cheng JQ, Zhang S, Lee JH, Buettner R, Mirosevich J, Lee FY, Jove R: Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer Res. 2005 Oct 15;65(20):9185-9. |
| Groups | Approved; Investigational |
| Direct Classification | Aromatic anilides |
| SMILES | CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1 |
| Pathways | Dasatinib Inhibition of BCR-ABL |
| PharmGKB | PA162372878 |
| ChEMBL | CHEMBL1421 |
