| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30080752 | HIV | ENSG00000197122.13 | protein_coding | SRC | Yes | No | 6714 | P12931 |
| TVIS30081124 | HIV | ENSG00000197122.13 | protein_coding | SRC | Yes | No | 6714 | P12931 |
| TVIS30020612 | HIV | ENSG00000197122.13 | protein_coding | SRC | Yes | No | 6714 | P12931 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | SRC |
|---|---|
| DrugBank ID | DB06137 |
| Drug Name | Tirbanibulin |
| Target ID | BE0000838 |
| UniProt ID | P12931 |
| Regulation Type | inhibitor |
| PubMed IDs | 21509526; 23314737 |
| Citations | Anbalagan M, Carrier L, Glodowski S, Hangauer D, Shan B, Rowan BG: KX-01, a novel Src kinase inhibitor directed toward the peptide substrate site, synergizes with tamoxifen in estrogen receptor alpha positive breast cancer. Breast Cancer Res Treat. 2012 Apr;132(2):391-409. doi: 10.1007/s10549-011-1513-3. Epub 2011 Apr 21.@@Antonarakis ES, Heath EI, Posadas EM, Yu EY, Harrison MR, Bruce JY, Cho SY, Wilding GE, Fetterly GJ, Hangauer DG, Kwan MF, Dyster LM, Carducci MA: A phase 2 study of KX2-391, an oral inhibitor of Src kinase and tubulin polymerization, in men with bone-metastatic castration-resistant prostate cancer. Cancer Chemother Pharmacol. 2013 Apr;71(4):883-92. doi: 10.1007/s00280-013-2079-z. Epub 2013 Jan 13. |
| Groups | Approved; Investigational |
| Direct Classification | |
| SMILES | O=C(CC1=CC=C(C=N1)C1=CC=C(OCCN2CCOCC2)C=C1)NCC1=CC=CC=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL571546 |
