| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30008124 | HIV | ENSG00000128271.22 | protein_coding | ADORA2A | No | No | 135 | P29274 X5DNB4 |
| TVIS44031350 | HTLV-1 | ENSG00000128271.22 | protein_coding | ADORA2A | No | No | 135 | P29274 X5DNB4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ADORA2A |
|---|---|
| DrugBank ID | DB01412 |
| Drug Name | Theobromine |
| Target ID | BE0000924 |
| UniProt ID | P29274 |
| Regulation Type | antagonist |
| PubMed IDs | 12602592; 17558310; 17577101; 17616786; 15095008; 3588607 |
| Citations | Chou CC, Vickroy TW: Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues. Am J Vet Res. 2003 Feb;64(2):216-24.@@Riksen NP, Franke B, van den Broek P, Smits P, Rongen GA: The 1976C>T polymorphism in the adenosine A2A receptor gene does not affect the vasodilator response to adenosine in humans in vivo. Pharmacogenet Genomics. 2007 Jul;17(7):551-4.@@Zhao G, Messina E, Xu X, Ochoa M, Sun HL, Leung K, Shryock J, Belardinelli L, Hintze TH: Caffeine attenuates the duration of coronary vasodilation and changes in hemodynamics induced by regadenoson (CVT-3146), a novel adenosine A2A receptor agonist. J Cardiovasc Pharmacol. 2007 Jun;49(6):369-75.@@Cornelis MC, El-Sohemy A, Campos H: Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. Am J Clin Nutr. 2007 Jul;86(1):240-4.@@Fisone G, Borgkvist A, Usiello A: Caffeine as a psychomotor stimulant: mechanism of action. Cell Mol Life Sci. 2004 Apr;61(7-8):857-72.@@Daly JW, Jacobson KA, Ukena D: Adenosine receptors: development of selective agonists and antagonists. Prog Clin Biol Res. 1987;230:41-63. |
| Groups | Investigational |
| Direct Classification | Xanthines |
| SMILES | CN1C=NC2=C1C(=O)NC(=O)N2C |
| Pathways | Caffeine Metabolism |
| PharmGKB | PA451646 |
| ChEMBL | CHEMBL1114 |
