| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20008608 | HPV | ENSG00000167434.10 | protein_coding | CA4 | No | No | 762 | P22748 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CA4 |
|---|---|
| DrugBank ID | DB01021 |
| Drug Name | Trichlormethiazide |
| Target ID | BE0000535 |
| UniProt ID | P22748 |
| Regulation Type | inhibitor |
| PubMed IDs | 17139284; 17016423; 19119014 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Temperini C, Cecchi A, Scozzafava A, Supuran CT: Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg Med Chem. 2009 Feb 1;17(3):1214-21. doi: 10.1016/j.bmc.2008.12.023. Epub 2008 Dec 24. |
| Groups | Approved; Vet_approved |
| Direct Classification | 1,2,4-benzothiadiazine-1,1-dioxides |
| SMILES | NS(=O)(=O)C1=C(Cl)C=C2NC(NS(=O)(=O)C2=C1)C(Cl)Cl |
| Pathways | Trichlormethiazide Action Pathway |
| PharmGKB | PA164752426 |
| ChEMBL | CHEMBL1054 |
