| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20061334 | HPV | ENSG00000196230.14 | protein_coding | TUBB | No | No | 203068 | P07437 Q5ST81 Q5SU16 |
| TVIS44034137 | HTLV-1 | ENSG00000196230.14 | protein_coding | TUBB | No | No | 203068 | P07437 Q5ST81 Q5SU16 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TUBB |
|---|---|
| DrugBank ID | DB06137 |
| Drug Name | Tirbanibulin |
| Target ID | BE0000143 |
| UniProt ID | P07437 |
| Regulation Type | inhibitor |
| PubMed IDs | 31628188; 22784709 |
| Citations | Niu L, Yang J, Yan W, Yu Y, Zheng Y, Ye H, Chen Q, Chen L: Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of beta-tubulin explains KXO1's low clinical toxicity. J Biol Chem. 2019 Nov 29;294(48):18099-18108. doi: 10.1074/jbc.RA119.010732. Epub 2019 Oct 18.@@Anbalagan M, Ali A, Jones RK, Marsden CG, Sheng M, Carrier L, Bu Y, Hangauer D, Rowan BG: Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts. Mol Cancer Ther. 2012 Sep;11(9):1936-47. doi: 10.1158/1535-7163.MCT-12-0146. Epub 2012 Jul 10. |
| Groups | Approved; Investigational |
| Direct Classification | |
| SMILES | O=C(CC1=CC=C(C=N1)C1=CC=C(OCCN2CCOCC2)C=C1)NCC1=CC=CC=C1 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL571546 |
