| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20061334 | HPV | ENSG00000196230.14 | protein_coding | TUBB | No | No | 203068 | P07437 Q5ST81 Q5SU16 |
| TVIS44034137 | HTLV-1 | ENSG00000196230.14 | protein_coding | TUBB | No | No | 203068 | P07437 Q5ST81 Q5SU16 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TUBB |
|---|---|
| DrugBank ID | DB11641 |
| Drug Name | Vinflunine |
| Target ID | BE0000143 |
| UniProt ID | P07437 |
| Regulation Type | inhibitor |
| PubMed IDs | 8663038; 19455242; 28042310 |
| Citations | Rai SS, Wolff J: Localization of the vinblastine-binding site on beta-tubulin. J Biol Chem. 1996 Jun 21;271(25):14707-11.@@Huzil JT, Chen K, Kurgan L, Tuszynski JA: The roles of beta-tubulin mutations and isotype expression in acquired drug resistance. Cancer Inform. 2007 Apr 27;3:159-81.@@Gerullis H, Wawroschek F, Kohne CH, Ecke TH: Vinflunine in the treatment of advanced urothelial cancer: clinical evidence and experience. Ther Adv Urol. 2017 Jan;9(1):28-35. doi: 10.1177/1756287216677903. Epub 2016 Nov 21. |
| Groups | Approved; Investigational |
| Direct Classification | Vinca alkaloids |
| SMILES | CC[C@@]12C=CCN3CC[C@@]4([C@H]13)[C@@H](N(C)C1=CC(OC)=C(C=C41)[C@]1(C[C@@H]3C[C@H](C[N@@](C3)CC3=C1NC1=CC=CC=C31)C(C)(F)F)C(=O)OC)[C@](O)([C@@H]2OC(C)=O)C(=O)OC |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2110725 |
