| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS20061334 | HPV | ENSG00000196230.14 | protein_coding | TUBB | No | No | 203068 | P07437 Q5ST81 Q5SU16 |
| TVIS44034137 | HTLV-1 | ENSG00000196230.14 | protein_coding | TUBB | No | No | 203068 | P07437 Q5ST81 Q5SU16 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | TUBB |
|---|---|
| DrugBank ID | DB00541 |
| Drug Name | Vincristine |
| Target ID | BE0000143 |
| UniProt ID | P07437 |
| Regulation Type | inhibitor |
| PubMed IDs | 17139284; 17016423; 19277662; 20442307 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Kurtzberg LS, Roth SD, Bagley RG, Rouleau C, Yao M, Crawford JL, Krumbholz RD, Schmid SM, Teicher BA: Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents. Cancer Chemother Pharmacol. 2009 Oct;64(5):1029-38. doi: 10.1007/s00280-009-0959-z. Epub 2009 Mar 10.@@Gan PP, McCarroll JA, Po'uha ST, Kamath K, Jordan MA, Kavallaris M: Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin. Mol Cancer Ther. 2010 May;9(5):1339-48. doi: 10.1158/1535-7163.MCT-09-0679. Epub 2010 May 4. |
| Groups | Approved; Investigational |
| Direct Classification | Vinca alkaloids |
| SMILES | [H][C@@]12N3CC[C@@]11C4=C(C=C(OC)C(=C4)[C@]4(C[C@H]5C[N@](C[C@](O)(CC)C5)CCC5=C4NC4=CC=CC=C54)C(=O)OC)N(C=O)[C@@]1([H])[C@](O)([C@H](OC(C)=O)[C@]2(CC)C=CC3)C(=O)OC |
| Pathways | Vincristine Action Pathway |
| PharmGKB | PA451879 |
| ChEMBL | CHEMBL499458 |
