| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30023045 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023046 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023047 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023048 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023049 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS44018658 | HTLV-1 | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | LCK |
|---|---|
| DrugBank ID | DB08901 |
| Drug Name | Ponatinib |
| Target ID | BE0000842 |
| UniProt ID | P06239 |
| Regulation Type | inhibitor |
| PubMed IDs | 23190395 |
| Citations | Gushwa NN, Kang S, Chen J, Taunton J: Selective targeting of distinct active site nucleophiles by irreversible SRC-family kinase inhibitors. J Am Chem Soc. 2012 Dec 19;134(50):20214-7. doi: 10.1021/ja310659j. Epub 2012 Dec 4. |
| Groups | Approved; Investigational |
| Direct Classification | Benzanilides |
| SMILES | CN1CCN(CC2=CC=C(NC(=O)C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C)C=C3)C=C2C(F)(F)F)CC1 |
| Pathways | Ponatinib Inhibition of BCR-ABL |
| PharmGKB | PA165980594 |
| ChEMBL | CHEMBL1171837 |
