| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30023045 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023046 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023047 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023048 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023049 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS44018658 | HTLV-1 | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | LCK |
|---|---|
| DrugBank ID | DB12010 |
| Drug Name | Fostamatinib |
| Target ID | BE0000842 |
| UniProt ID | P06239 |
| Regulation Type | inhibitor |
| PubMed IDs | 26516587 |
| Citations | Rolf MG, Curwen JO, Veldman-Jones M, Eberlein C, Wang J, Harmer A, Hellawell CJ, Braddock M: In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib. Pharmacol Res Perspect. 2015 Oct;3(5):e00175. doi: 10.1002/prp2.175. Epub 2015 Sep 4. |
| Groups | Approved; Investigational |
| Direct Classification | Methoxyanilines |
| SMILES | COC1=CC(NC2=NC=C(F)C(NC3=NC4=C(OC(C)(C)C(=O)N4COP(O)(O)=O)C=C3)=N2)=CC(OC)=C1OC |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL2103830 |
