| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30023045 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023046 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023047 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023048 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS30023049 | HIV | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
| TVIS44018658 | HTLV-1 | ENSG00000182866.18 | protein_coding | LCK | Yes | No | 3932 | A0A0S2Z3Y4 A0A0S2Z3Y8 P06239 Q573B4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | LCK |
|---|---|
| DrugBank ID | DB16656 |
| Drug Name | Zotiraciclib |
| Target ID | BE0000842 |
| UniProt ID | P06239 |
| Regulation Type | inhibitor |
| PubMed IDs | 33714981 |
| Citations | Chen R, Tsai J, Thompson PA, Chen Y, Xiong P, Liu C, Burrows F, Sivina M, Burger JA, Keating MJ, Wierda WG, Plunkett W: The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action. Blood Cancer J. 2021 Mar 13;11(3):57. doi: 10.1038/s41408-021-00436-0. |
| Groups | Investigational |
| Direct Classification | |
| SMILES | CN1CC=CCCOC2=CC(=CC=C2)C2=CC=NC(NC3=CC=CC(C1)=C3)=N2 |
| Pathways | |
| PharmGKB | |
| ChEMBL | CHEMBL1944698 |
