| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30054123 | HIV | ENSG00000101204.18 | protein_coding | CHRNA4 | No | No | 1137 | P43681 Q4VAQ3 |
| TVIS20067223 | HPV | ENSG00000101204.18 | protein_coding | CHRNA4 | No | No | 1137 | P43681 Q4VAQ3 |
| TVIS20037058 | HPV | ENSG00000101204.18 | protein_coding | CHRNA4 | No | No | 1137 | P43681 Q4VAQ3 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CHRNA4 |
|---|---|
| DrugBank ID | DB00753 |
| Drug Name | Isoflurane |
| Target ID | BE0000849 |
| UniProt ID | P43681 |
| Regulation Type | antagonist |
| PubMed IDs | 20660787; 12131122; 15618790 |
| Citations | Brannigan G, LeBard DN, Henin J, Eckenhoff RG, Klein ML: Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14122-7. doi: 10.1073/pnas.1008534107. Epub 2010 Jul 26.@@Flood P, Sonner JM, Gong D, Coates KM: Isoflurane hyperalgesia is modulated by nicotinic inhibition. Anesthesiology. 2002 Jul;97(1):192-8.@@Yamashita M, Mori T, Nagata K, Yeh JZ, Narahashi T: Isoflurane modulation of neuronal nicotinic acetylcholine receptors expressed in human embryonic kidney cells. Anesthesiology. 2005 Jan;102(1):76-84. |
| Groups | Approved; Vet_approved |
| Direct Classification | Organofluorides |
| SMILES | FC(F)OC(Cl)C(F)(F)F |
| Pathways | |
| PharmGKB | PA450106 |
| ChEMBL | CHEMBL1256 |
