| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30027118 | HIV | ENSG00000196139.14 | protein_coding | AKR1C3 | No | No | 8644 | A0A0A0MSS8 P42330 |
| TVIS20007304 | HPV | ENSG00000196139.14 | protein_coding | AKR1C3 | No | No | 8644 | A0A0A0MSS8 P42330 |
| TVIS20007305 | HPV | ENSG00000196139.14 | protein_coding | AKR1C3 | No | No | 8644 | A0A0A0MSS8 P42330 |
| TVIS20007306 | HPV | ENSG00000196139.14 | protein_coding | AKR1C3 | No | No | 8644 | A0A0A0MSS8 P42330 |
| TVIS20013263 | HPV | ENSG00000196139.14 | protein_coding | AKR1C3 | No | No | 8644 | A0A0A0MSS8 P42330 |
| TVIS20021893 | HPV | ENSG00000196139.14 | protein_coding | AKR1C3 | No | No | 8644 | A0A0A0MSS8 P42330 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | AKR1C3 |
|---|---|
| DrugBank ID | DB00328 |
| Drug Name | Indomethacin |
| Target ID | BE0000592 |
| UniProt ID | P42330 |
| Regulation Type | inhibitor |
| PubMed IDs | 14996743; 27486833 |
| Citations | Lovering AL, Ride JP, Bunce CM, Desmond JC, Cummings SM, White SA: Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin. Cancer Res. 2004 Mar 1;64(5):1802-10.@@Adeniji A, Uddin MJ, Zang T, Tamae D, Wangtrakuldee P, Marnett LJ, Penning TM: Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor. J Med Chem. 2016 Aug 25;59(16):7431-44. doi: 10.1021/acs.jmedchem.6b00160. Epub 2016 Aug 12. |
| Groups | Approved; Investigational |
| Direct Classification | Benzoylindoles |
| SMILES | COC1=CC2=C(C=C1)N(C(=O)C1=CC=C(Cl)C=C1)C(C)=C2CC(O)=O |
| Pathways | Indomethacin Action Pathway |
| PharmGKB | PA449982 |
| ChEMBL | CHEMBL6 |
