| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10033916 | HBV | ENSG00000137869.16 | protein_coding | CYP19A1 | Yes | No | 1588 | P11511 Q05CU4 Q8IYG4 |
| TVIS30013901 | HIV | ENSG00000137869.16 | protein_coding | CYP19A1 | Yes | No | 1588 | P11511 Q05CU4 Q8IYG4 |
| TVIS30038294 | HIV | ENSG00000137869.16 | protein_coding | CYP19A1 | Yes | No | 1588 | P11511 Q05CU4 Q8IYG4 |
| TVIS20042103 | HPV | ENSG00000137869.16 | protein_coding | CYP19A1 | Yes | No | 1588 | P11511 Q05CU4 Q8IYG4 |
| TVIS20066497 | HPV | ENSG00000137869.16 | protein_coding | CYP19A1 | Yes | No | 1588 | P11511 Q05CU4 Q8IYG4 |
| TVIS20052205 | HPV | ENSG00000137869.16 | protein_coding | CYP19A1 | Yes | No | 1588 | P11511 Q05CU4 Q8IYG4 |
| TVIS44008818 | HTLV-1 | ENSG00000137869.16 | protein_coding | CYP19A1 | Yes | No | 1588 | P11511 Q05CU4 Q8IYG4 |
| TVIS44041779 | HTLV-1 | ENSG00000137869.16 | protein_coding | CYP19A1 | Yes | No | 1588 | P11511 Q05CU4 Q8IYG4 |
| TVIS44036552 | HTLV-1 | ENSG00000137869.16 | protein_coding | CYP19A1 | Yes | No | 1588 | P11511 Q05CU4 Q8IYG4 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CYP19A1 |
|---|---|
| DrugBank ID | DB00357 |
| Drug Name | Aminoglutethimide |
| Target ID | BE0002090 |
| UniProt ID | P11511 |
| Regulation Type | inhibitor |
| PubMed IDs | 17139284; 17016423; 16332571; 16244789; 16474421; 17602675; 11752352 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Greco F, Vicent MJ, Penning NA, Nicholson RI, Duncan R: HPMA copolymer-aminoglutethimide conjugates inhibit aromatase in MCF-7 cell lines. J Drug Target. 2005 Sep-Nov;13(8-9):459-70.@@Martinez-Campa C, Gonzalez A, Mediavilla MD, Alonso-Gonzalez C, Sanchez-Barcelo EJ, Cos S: Melatonin enhances the inhibitory effect of aminoglutethimide on aromatase activity in MCF-7 human breast cancer cells. Breast Cancer Res Treat. 2005 Dec;94(3):249-54. Epub 2005 Oct 22.@@Shirakawa H, Katsuki H, Kume T, Kaneko S, Akaike A: Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons. Br J Pharmacol. 2006 Apr;147(7):729-36.@@Siraki AG, Bonini MG, Jiang J, Ehrenshaft M, Mason RP: Aminoglutethimide-induced protein free radical formation on myeloperoxidase: a potential mechanism of agranulocytosis. Chem Res Toxicol. 2007 Jul;20(7):1038-45. Epub 2007 Jun 30.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational |
| Direct Classification | Aniline and substituted anilines |
| SMILES | CCC1(CCC(=O)NC1=O)C1=CC=C(N)C=C1 |
| Pathways | |
| PharmGKB | PA448375 |
| ChEMBL | CHEMBL488 |
