| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10005318 | HBV | ENSG00000196591.12 | protein_coding | HDAC2 | Yes | No | 3066 | Q92769 |
| TVIS30010961 | HIV | ENSG00000196591.12 | protein_coding | HDAC2 | Yes | No | 3066 | Q92769 |
| TVIS20004407 | HPV | ENSG00000196591.12 | protein_coding | HDAC2 | Yes | No | 3066 | Q92769 |
| TVIS44011440 | HTLV-1 | ENSG00000196591.12 | protein_coding | HDAC2 | Yes | No | 3066 | Q92769 |
| TVIS44011749 | HTLV-1 | ENSG00000196591.12 | protein_coding | HDAC2 | Yes | No | 3066 | Q92769 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HDAC2 |
|---|---|
| DrugBank ID | DB00227 |
| Drug Name | Lovastatin |
| Target ID | BE0002366 |
| UniProt ID | Q92769 |
| Regulation Type | inhibitor |
| PubMed IDs | 18381445; 30266498; 30216432 |
| Citations | Lin YC, Lin JH, Chou CW, Chang YF, Yeh SH, Chen CC: Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. Cancer Res. 2008 Apr 1;68(7):2375-83. doi: 10.1158/0008-5472.CAN-07-5807.@@Zhang L, Kang W, Lu X, Ma S, Dong L, Zou B: Weighted gene co-expression network analysis and connectivity map identifies lovastatin as a treatment option of gastric cancer by inhibiting HDAC2. Gene. 2019 Jan 10;681:15-25. doi: 10.1016/j.gene.2018.09.040. Epub 2018 Sep 25.@@Luthje P, Walker S, Kamolvit W, Mohanty S, Putsep K, Brauner A: Statins influence epithelial expression of the anti-microbial peptide LL-37/hCAP-18 independently of the mevalonate pathway. Clin Exp Immunol. 2019 Feb;195(2):265-276. doi: 10.1111/cei.13217. Epub 2018 Oct 11. |
| Groups | Approved; Investigational |
| Direct Classification | Delta valerolactones |
| SMILES | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC |
| Pathways | Lovastatin Action Pathway |
| PharmGKB | PA450272 |
| ChEMBL | CHEMBL503 |
