| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30088483 | HIV | ENSG00000164270.19 | protein_coding | HTR4 | No | No | 3360 | A0A2D3FAF9 Q13639 |
| TVIS30063793 | HIV | ENSG00000164270.19 | protein_coding | HTR4 | No | No | 3360 | A0A2D3FAF9 Q13639 |
| TVIS30063794 | HIV | ENSG00000164270.19 | protein_coding | HTR4 | No | No | 3360 | A0A2D3FAF9 Q13639 |
| TVIS20008491 | HPV | ENSG00000164270.19 | protein_coding | HTR4 | No | No | 3360 | A0A2D3FAF9 Q13639 |
| TVIS20043606 | HPV | ENSG00000164270.19 | protein_coding | HTR4 | No | No | 3360 | A0A2D3FAF9 Q13639 |
| TVIS20023643 | HPV | ENSG00000164270.19 | protein_coding | HTR4 | No | No | 3360 | A0A2D3FAF9 Q13639 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | HTR4 |
|---|---|
| DrugBank ID | DB00604 |
| Drug Name | Cisapride |
| Target ID | BE0000084 |
| UniProt ID | Q13639 |
| Regulation Type | agonist |
| PubMed IDs | 10027842; 10328995; 10556228; 11034583; 11218067; 11752352 |
| Citations | Crema F, Modini C, Croci T, Langlois M, de Ponti F: Intestinal prokinesia by two esters of 4-amino-5-chloro-2- methoxybenzoic acid: involvement of 5-hydroxytryptamine-4 receptors and dissociation from cardiac effects in vivo. J Pharmacol Exp Ther. 1999 Mar;288(3):1045-52.@@Nagakura Y, Akuzawa S, Miyata K, Kamato T, Suzuki T, Ito H, Yamaguchi T: Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT4 receptor versus human 5-HT3 receptor. Pharmacol Res. 1999 May;39(5):375-82.@@Rahme MM, Cotter B, Leistad E, Wadhwa MK, Mohabir R, Ford AP, Eglen RM, Feld GK: Electrophysiological and antiarrhythmic effects of the atrial selective 5-HT(4) receptor antagonist RS-100302 in experimental atrial flutter and fibrillation. Circulation. 1999 Nov 9;100(19):2010-7.@@Bharucha AE, Camilleri M, Haydock S, Ferber I, Burton D, Cooper S, Tompson D, Fitzpatrick K, Higgins R, Zinsmeister AR: Effects of a serotonin 5-HT(4) receptor antagonist SB-207266 on gastrointestinal motor and sensory function in humans. Gut. 2000 Nov;47(5):667-74.@@Bach T, Syversveen T, Kvingedal AM, Krobert KA, Brattelid T, Kaumann AJ, Levy FO: 5HT4(a) and 5-HT4(b) receptors have nearly identical pharmacology and are both expressed in human atrium and ventricle. Naunyn Schmiedebergs Arch Pharmacol. 2001 Feb;363(2):146-60.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. |
| Groups | Approved; Investigational; Withdrawn |
| Direct Classification | Aminobenzamides |
| SMILES | CO[C@H]1CN(CCCOC2=CC=C(F)C=C2)CC[C@H]1NC(=O)C1=CC(Cl)=C(N)C=C1OC |
| Pathways | |
| PharmGKB | PA449011 |
| ChEMBL | CHEMBL560739 |
