Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS30004395HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30005737HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028946HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028947HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028948HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028949HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028950HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028951HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028952HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TCGA Plot Options
Drug Information
GeneRRM1
DrugBank IDDB00441
Drug NameGemcitabine
Target IDBE0000325
UniProt IDP23921
Regulation Typeinhibitor
PubMed IDs16708051; 16807441; 16966686; 17065054; 17131328; 17636467
CitationsKwon WS, Rha SY, Choi YH, Lee JO, Park KH, Jung JJ, Kim TS, Jeung HC, Chung HC: Ribonucleotide reductase M1 (RRM1) 2464G>A polymorphism shows an association with gemcitabine chemosensitivity in cancer cell lines. Pharmacogenet Genomics. 2006 Jun;16(6):429-38.@@Rosell R, Cobo M, Isla D, Camps C, Massuti B: Pharmacogenomics and gemcitabine. Ann Oncol. 2006 May;17 Suppl 5:v13-16.@@Bepler G, Kusmartseva I, Sharma S, Gautam A, Cantor A, Sharma A, Simon G: RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer. J Clin Oncol. 2006 Oct 10;24(29):4731-7. Epub 2006 Sep 11.@@Smid K, Bergman AM, Eijk PP, Veerman G, van Haperen VW, van den Ijssel P, Ylstra B, Peters GJ: Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits. Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1001-7.@@Nakahira S, Nakamori S, Tsujie M, Takahashi Y, Okami J, Yoshioka S, Yamasaki M, Marubashi S, Takemasa I, Miyamoto A, Takeda Y, Nagano H, Dono K, Umeshita K, Sakon M, Monden M: Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. Int J Cancer. 2007 Mar 15;120(6):1355-63.@@Cerqueira NM, Fernandes PA, Ramos MJ: Understanding ribonucleotide reductase inactivation by gemcitabine. Chemistry. 2007;13(30):8507-15.
GroupsApproved
Direct ClassificationPyrimidine 2'-deoxyribonucleosides
SMILESNC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)C1(F)F
PathwaysGemcitabine Metabolism Pathway; Gemcitabine Action Pathway
PharmGKBPA449748
ChEMBLCHEMBL888