VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
---|---|---|---|---|---|---|---|---|
TVIS30004395 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
TVIS30005737 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
TVIS30028946 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
TVIS30028947 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
TVIS30028948 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
TVIS30028949 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
TVIS30028950 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
TVIS30028951 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
TVIS30028952 | HIV | ENSG00000167325.15 | protein_coding | RRM1 | No | No | 6240 | E9PL69 P23921 |
Target Gene Table
▼
TCGA Plot Options
▼
Drug Information
▼
Gene | RRM1 |
---|---|
DrugBank ID | DB00441 |
Drug Name | Gemcitabine |
Target ID | BE0000325 |
UniProt ID | P23921 |
Regulation Type | inhibitor |
PubMed IDs | 16708051; 16807441; 16966686; 17065054; 17131328; 17636467 |
Citations | Kwon WS, Rha SY, Choi YH, Lee JO, Park KH, Jung JJ, Kim TS, Jeung HC, Chung HC: Ribonucleotide reductase M1 (RRM1) 2464G>A polymorphism shows an association with gemcitabine chemosensitivity in cancer cell lines. Pharmacogenet Genomics. 2006 Jun;16(6):429-38.@@Rosell R, Cobo M, Isla D, Camps C, Massuti B: Pharmacogenomics and gemcitabine. Ann Oncol. 2006 May;17 Suppl 5:v13-16.@@Bepler G, Kusmartseva I, Sharma S, Gautam A, Cantor A, Sharma A, Simon G: RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer. J Clin Oncol. 2006 Oct 10;24(29):4731-7. Epub 2006 Sep 11.@@Smid K, Bergman AM, Eijk PP, Veerman G, van Haperen VW, van den Ijssel P, Ylstra B, Peters GJ: Micro-array analysis of resistance for gemcitabine results in increased expression of ribonucleotide reductase subunits. Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):1001-7.@@Nakahira S, Nakamori S, Tsujie M, Takahashi Y, Okami J, Yoshioka S, Yamasaki M, Marubashi S, Takemasa I, Miyamoto A, Takeda Y, Nagano H, Dono K, Umeshita K, Sakon M, Monden M: Involvement of ribonucleotide reductase M1 subunit overexpression in gemcitabine resistance of human pancreatic cancer. Int J Cancer. 2007 Mar 15;120(6):1355-63.@@Cerqueira NM, Fernandes PA, Ramos MJ: Understanding ribonucleotide reductase inactivation by gemcitabine. Chemistry. 2007;13(30):8507-15. |
Groups | Approved |
Direct Classification | Pyrimidine 2'-deoxyribonucleosides |
SMILES | NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](CO)[C@@H](O)C1(F)F |
Pathways | Gemcitabine Metabolism Pathway; Gemcitabine Action Pathway |
PharmGKB | PA449748 |
ChEMBL | CHEMBL888 |