Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS30004395HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30005737HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028946HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028947HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028948HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028949HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028950HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028951HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028952HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TCGA Plot Options
Drug Information
GeneRRM1
DrugBank IDDB01073
Drug NameFludarabine
Target IDBE0000325
UniProt IDP23921
Regulation Typeinhibitor
PubMed IDs17139284; 17016423; 19519505; 19325518
CitationsOverington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Lech-Maranda E, Korycka A, Robak T: Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity. Mini Rev Med Chem. 2009 Jun;9(7):805-12.@@Robak T, Korycka A, Lech-Maranda E, Robak P: Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases. Molecules. 2009 Mar 23;14(3):1183-226. doi: 10.3390/molecules14031183.
GroupsApproved
Direct ClassificationPurine nucleosides
SMILESNC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
Pathways
PharmGKBPA449655
ChEMBLCHEMBL1568