Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS30004395HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30005737HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028946HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028947HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028948HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028949HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028950HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028951HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TVIS30028952HIVENSG00000167325.15protein_codingRRM1NoNo6240E9PL69
P23921
TCGA Plot Options
Drug Information
GeneRRM1
DrugBank IDDB01005
Drug NameHydroxyurea
Target IDBE0000325
UniProt IDP23921
Regulation Typeinhibitor
PubMed IDs15075397; 14583450; 20462199; 20005847
CitationsCulligan K, Tissier A, Britt A: ATR regulates a G2-phase cell-cycle checkpoint in Arabidopsis thaliana. Plant Cell. 2004 May;16(5):1091-104. Epub 2004 Apr 9.@@Zhou B, Liu X, Mo X, Xue L, Darwish D, Qiu W, Shih J, Hwu EB, Luh F, Yen Y: The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53. Cancer Res. 2003 Oct 15;63(20):6583-94.@@Jiang W, Xie J, Varano PT, Krebs C, Bollinger JM Jr: Two distinct mechanisms of inactivation of the class Ic ribonucleotide reductase from Chlamydia trachomatis by hydroxyurea: implications for the protein gating of intersubunit electron transfer. Biochemistry. 2010 Jun 29;49(25):5340-9. doi: 10.1021/bi100037b.@@Davies BW, Kohanski MA, Simmons LA, Winkler JA, Collins JJ, Walker GC: Hydroxyurea induces hydroxyl radical-mediated cell death in Escherichia coli. Mol Cell. 2009 Dec 11;36(5):845-60. doi: 10.1016/j.molcel.2009.11.024.
GroupsApproved
Direct ClassificationCarboximidic acids and derivatives
SMILESNC(=O)NO
Pathways
PharmGKBPA449942
ChEMBLCHEMBL467