| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44015196 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44002399 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44010875 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44034377 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44049463 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44035588 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CACNA1C |
|---|---|
| DrugBank ID | DB01388 |
| Drug Name | Mibefradil |
| Target ID | BE0000430 |
| UniProt ID | Q13936 |
| Regulation Type | inhibitor |
| PubMed IDs | 16306443; 16899990; 10372226; 10665814 |
| Citations | Moosmang S, Haider N, Bruderl B, Welling A, Hofmann F: Antihypertensive effects of the putative T-type calcium channel antagonist mibefradil are mediated by the L-type calcium channel Cav1.2. Circ Res. 2006 Jan 6;98(1):105-10. Epub 2005 Nov 23.@@Lee TS, Kaku T, Takebayashi S, Uchino T, Miyamoto S, Hadama T, Perez-Reyes E, Ono K: Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology. 2006;78(1):11-20. Epub 2006 Aug 7.@@Mocanu MM, Gadgil S, Yellon DM, Baxter GF: Mibefradil, a T-type and L-type calcium channel blocker, limits infarct size through a glibenclamide-sensitive mechanism. Cardiovasc Drugs Ther. 1999 Apr;13(2):115-22.@@Jimenez C, Bourinet E, Leuranguer V, Richard S, Snutch TP, Nargeot J: Determinants of voltage-dependent inactivation affect Mibefradil block of calcium channels. Neuropharmacology. 2000;39(1):1-10. |
| Groups | Investigational; Withdrawn |
| Direct Classification | Tetralins |
| SMILES | COCC(=O)O[C@]1(CCN(C)CCCC2=NC3=CC=CC=C3N2)CCC2=C(C=CC(F)=C2)[C@@H]1C(C)C |
| Pathways | |
| PharmGKB | PA450492 |
| ChEMBL | CHEMBL45816 |
