| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44015196 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44002399 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44010875 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44034377 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44049463 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44035588 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CACNA1C |
|---|---|
| DrugBank ID | DB00270 |
| Drug Name | Isradipine |
| Target ID | BE0000430 |
| UniProt ID | Q13936 |
| Regulation Type | inhibitor |
| PubMed IDs | 10766758; 12135765; 9607315 |
| Citations | Berjukow S, Marksteiner R, Gapp F, Sinnegger MJ, Hering S: Molecular mechanism of calcium channel block by isradipine. Role of a drug-induced inactivated channel conformation. J Biol Chem. 2000 Jul 21;275(29):22114-20.@@Hitzl M, Striessnig J, Neuhuber B, Flucher BE: A mutation in the beta interaction domain of the Ca(2+) channel alpha(1C) subunit reduces the affinity of the (+)-[(3)H]isradipine binding site. FEBS Lett. 2002 Jul 31;524(1-3):188-92.@@Zuhlke RD, Bouron A, Soldatov NM, Reuter H: Ca2+ channel sensitivity towards the blocker isradipine is affected by alternative splicing of the human alpha1C subunit gene. FEBS Lett. 1998 May 8;427(2):220-4. |
| Groups | Approved; Investigational |
| Direct Classification | Benzoxadiazoles |
| SMILES | COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C |
| Pathways | Isradipine Action Pathway |
| PharmGKB | PA450131 |
| ChEMBL | CHEMBL1648 |
