| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS44015196 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44002399 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44010875 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44034377 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44049463 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
| TVIS44035588 | HTLV-1 | ENSG00000151067.23 | protein_coding | CACNA1C | No | No | 775 | A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q5V9X9 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | CACNA1C |
|---|---|
| DrugBank ID | DB06751 |
| Drug Name | Drotaverine |
| Target ID | BE0008715 |
| UniProt ID | O00555 |
| Regulation Type | inhibitor |
| PubMed IDs | 12163106; 12823389; 27738091 |
| Citations | Tomoskozi Z, Finance O, Aranyi P: Drotaverine interacts with the L-type Ca(2+) channel in pregnant rat uterine membranes. Eur J Pharmacol. 2002 Aug 2;449(1-2):55-60.@@Romics I, Molnar DL, Timberg G, Mrklic B, Jelakovic B, Koszegi G, Blasko G: The effect of drotaverine hydrochloride in acute colicky pain caused by renal and ureteric stones. BJU Int. 2003 Jul;92(1):92-6.@@Patai Z, Guttman A, Mikus EG: Potential L-Type Voltage-Operated Calcium Channel Blocking Effect of Drotaverine on Functional Models. J Pharmacol Exp Ther. 2016 Dec;359(3):442-451. doi: 10.1124/jpet.116.237271. Epub 2016 Oct 13. |
| Groups | Approved; Investigational |
| Direct Classification | Tetrahydroisoquinolines |
| SMILES | CCOC1=C(OCC)C=C(C=C2/NCCC3=CC(OCC)=C(OCC)C=C23)C=C1 |
| Pathways | |
| PharmGKB | PA165958398 |
| ChEMBL | CHEMBL551978 |
