Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS42000557EBVENSG00000108576.10protein_codingSLC6A4NoNo6532P31645
TVIS20001603HPVENSG00000108576.10protein_codingSLC6A4NoNo6532P31645
TVIS20029318HPVENSG00000108576.10protein_codingSLC6A4NoNo6532P31645
TVIS20031248HPVENSG00000108576.10protein_codingSLC6A4NoNo6532P31645
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Drug Information
GeneSLC6A4
DrugBank IDDB00907
Drug NameCocaine
Target IDBE0000749
UniProt IDP31645
Regulation Typeinhibitor
PubMed IDs12057823; 10366604; 8302852; 15351386; 9537821
CitationsPatkar AA, Berrettini WH, Hoehe M, Thornton CC, Gottheil E, Hill K, Weinstein SP: Serotonin transporter polymorphisms and measures of impulsivity, aggression, and sensation seeking among African-American cocaine-dependent individuals. Psychiatry Res. 2002 Jun 1;110(2):103-15.@@Barker EL, Moore KR, Rakhshan F, Blakely RD: Transmembrane domain I contributes to the permeation pathway for serotonin and ions in the serotonin transporter. J Neurosci. 1999 Jun 15;19(12):4705-17.@@Corey JL, Quick MW, Davidson N, Lester HA, Guastella J: A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization. Proc Natl Acad Sci U S A. 1994 Feb 1;91(3):1188-92.@@Carrera MR, Meijler MM, Janda KD: Cocaine pharmacology and current pharmacotherapies for its abuse. Bioorg Med Chem. 2004 Oct 1;12(19):5019-30.@@Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58.
GroupsApproved; Illicit
Direct ClassificationBenzoic acid esters
SMILES[H][C@]12CC[C@]([H])([C@H]([C@H](C1)OC(=O)C1=CC=CC=C1)C(=O)OC)N2C
PathwaysCocaine Action Pathway
PharmGKBPA449072
ChEMBLCHEMBL370805