Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS42000557EBVENSG00000108576.10protein_codingSLC6A4NoNo6532P31645
TVIS20001603HPVENSG00000108576.10protein_codingSLC6A4NoNo6532P31645
TVIS20029318HPVENSG00000108576.10protein_codingSLC6A4NoNo6532P31645
TVIS20031248HPVENSG00000108576.10protein_codingSLC6A4NoNo6532P31645
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Drug Information
GeneSLC6A4
DrugBank IDDB00191
Drug NamePhentermine
Target IDBE0000749
UniProt IDP31645
Regulation Typeinhibitor
PubMed IDs17459426; 14675103; 16380550; 10458725; 16644904
CitationsJohn CE, Jones SR: Voltammetric characterization of the effect of monoamine uptake inhibitors and releasers on dopamine and serotonin uptake in mouse caudate-putamen and substantia nigra slices. Neuropharmacology. 2007 Jun;52(8):1596-605. Epub 2007 Mar 16.@@Johnson GJ, Leis LA, Dunlop PC, Weir EK: The effect of the anorectic agent, d-fenfluramine, and its primary metabolite, d-norfenfluramine, on intact human platelet serotonin uptake and efflux. J Thromb Haemost. 2003 Dec;1(12):2663-8.@@Mekontso-Dessap A, Brouri F, Pascal O, Lechat P, Hanoun N, Lanfumey L, Seif I, Benhaiem-Sigaux N, Kirsch M, Hamon M, Adnot S, Eddahibi S: Deficiency of the 5-hydroxytryptamine transporter gene leads to cardiac fibrosis and valvulopathy in mice. Circulation. 2006 Jan 3;113(1):81-9. Epub 2005 Dec 27.@@Rothman RB, Ayestas MA, Dersch CM, Baumann MH: Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation. 1999 Aug 24;100(8):869-75.@@Zolkowska D, Rothman RB, Baumann MH: Amphetamine analogs increase plasma serotonin: implications for cardiac and pulmonary disease. J Pharmacol Exp Ther. 2006 Aug;318(2):604-10. Epub 2006 Apr 27.
GroupsApproved; Illicit
Direct ClassificationAmphetamines and derivatives
SMILESCC(C)(N)CC1=CC=CC=C1
Pathways
PharmGKBPA164748099
ChEMBLCHEMBL1574