| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30007896 | HIV | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS30052334 | HIV | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS30052335 | HIV | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037937 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037738 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037936 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44044411 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037935 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ATIC |
|---|---|
| DrugBank ID | DB00642 |
| Drug Name | Pemetrexed |
| Target ID | BE0001240 |
| UniProt ID | P31939 |
| Regulation Type | inhibitor |
| PubMed IDs | 12571811; 11524555; 19549896 |
| Citations | Kindler HL: Pemetrexed in pancreatic cancer. Semin Oncol. 2002 Dec;29(6 Suppl 18):49-53.@@Hanauske AR, Chen V, Paoletti P, Niyikiza C: Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors. Oncologist. 2001;6(4):363-73.@@Racanelli AC, Rothbart SB, Heyer CL, Moran RG: Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition. Cancer Res. 2009 Jul 1;69(13):5467-74. doi: 10.1158/0008-5472.CAN-08-4979. Epub 2009 Jun 23. |
| Groups | Approved; Investigational |
| Direct Classification | Glutamic acid and derivatives |
| SMILES | NC1=NC(=O)C2=C(NC=C2CCC2=CC=C(C=C2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N1 |
| Pathways | |
| PharmGKB | PA10810 |
| ChEMBL | CHEMBL225072 |
