| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS30007896 | HIV | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS30052334 | HIV | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS30052335 | HIV | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037937 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037738 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037936 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44044411 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
| TVIS44037935 | HTLV-1 | ENSG00000138363.15 | protein_coding | ATIC | Yes | No | 471 | P31939 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | ATIC |
|---|---|
| DrugBank ID | DB01700 |
| Drug Name | AICA ribonucleotide |
| Target ID | BE0001240 |
| UniProt ID | P31939 |
| Regulation Type | |
| PubMed IDs | 17139284; 17016423; 10592235 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
| Groups | Experimental; Investigational |
| Direct Classification | 1-ribosyl-imidazolecarboxamides |
| SMILES | NC(=O)C1=C(N)N(C=N1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O |
| Pathways | Gout or Kelley-Seegmiller Syndrome; Purine Metabolism; Lesch-Nyhan Syndrome (LNS); Myoadenylate Deaminase Deficiency; Molybdenum Cofactor Deficiency; Adenine Phosphoribosyltransferase Deficiency (APRT); Mercaptopurine Action Pathway; Xanthinuria Type I; Azathioprine Action Pathway; AICA-Ribosiduria; Thioguanine Action Pathway; Mitochondrial DNA Depletion Syndrome; Adenosine Deaminase Deficiency; Xanthine Dehydrogenase Deficiency (Xanthinuria); Purine Nucleoside Phosphorylase Deficiency; Adenylosuccinate Lyase Deficiency; Xanthinuria Type II |
| PharmGKB | |
| ChEMBL | CHEMBL483849 |
